Expression of NPEPPS in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

NPEPPS

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NPEPPS
Gene description	Aminopeptidase puromycin sensitive
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA021453 , HPA045649
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and liver cancer (unfavourable).
Colorectal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021453	HPA045649

GENE INFORMATION
Gene name	NPEPPS (HGNC Symbol)
Synonyms	MP100, PSA
Description	Aminopeptidase puromycin sensitive (HGNC Symbol)
Entrez gene summary	This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	47522942 - 47623276
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141279 (version 83.38)
Entrez gene	9520
UniProt	P55786 (UniProt - Evidence at protein level)
neXtProt	NX_P55786
Antibodypedia	NPEPPS antibodies

PROTEIN BROWSER

NPEPPS-001	NPEPPS-002	NPEPPS-011	NPEPPS-020	NPEPPS-021	NPEPPS-027

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPEPPS-001 ENSP00000320324 ENST00000322157	P55786 [Direct mapping] Puromycin-sensitive aminopeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000209 [protein polyubiquitination] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0004177 [aminopeptidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0042277 [peptide binding] GO:0043171 [peptide catabolic process] GO:0070006 [metalloaminopeptidase activity] GO:0070062 [extracellular exosome] GO:0071456 [cellular response to hypoxia] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	919 aa 103.3 kDa	No	0
NPEPPS-002 ENSP00000433287 ENST00000530173	E9PLK3 [Direct mapping] Puromycin-sensitive aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	915 aa 103 kDa	No	0
NPEPPS-011 ENSP00000437019 ENST00000525007	E9PP11 [Direct mapping] Puromycin-sensitive aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	201 aa 22.3 kDa	No	0
NPEPPS-020 ENSP00000435966 ENST00000527360	E9PRQ5 [Direct mapping] Puromycin-sensitive aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	172 aa 20 kDa	No	0
NPEPPS-021 ENSP00000435639 ENST00000527964	E9PJ74 [Direct mapping] Puromycin-sensitive aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	158 aa 18.3 kDa	No	0
NPEPPS-027 ENSP00000433549 ENST00000528565	H0YDG0 [Direct mapping] Puromycin-sensitive aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] Show all	169 aa 19.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.