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CLTC

GENERAL INFORMATION

Gene name

 CLTC

Gene description

 Clathrin, heavy chain (Hc)

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 4 antibodies.
HPA059143 , CAB010389 , CAB011571 , CAB017155
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable), liver cancer (unfavourable), cervical cancer (unfavourable) and colorectal cancer (favourable).
Urothelial cancer p<0.001
Liver cancer p<0.001
Cervical cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA059143
CAB010389
CAB011571
CAB017155

GENE INFORMATION

Gene name

 CLTC (HGNC Symbol)

Synonyms

 CLTCL2, Hc

Description

 Clathrin, heavy chain (Hc) (HGNC Symbol)

Entrez gene summary

 Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q23.1

Chromosome location (bp)

 59619689 - 59696956

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141367 (version 83.38)

Entrez gene

 1213

UniProt

 Q00610 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00610

Antibodypedia

 CLTC antibodies

PROTEIN BROWSER
CLTC-001
CLTC-002
CLTC-008
CLTC-009
CLTC-010
CLTC-014
CLTC-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLTC-001
ENSP00000269122
ENST00000269122
Q00610 [Direct mapping]
Clathrin heavy chain 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003725 [double-stranded RNA binding]
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007067 [mitotic nuclear division]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030118 [clathrin coat]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
GO:0030136 [clathrin-coated vesicle]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0032051 [clathrin light chain binding]
GO:0032588 [trans-Golgi network membrane]
GO:0033572 [transferrin transport]
GO:0036020 [endolysosome membrane]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042470 [melanosome]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071439 [clathrin complex]
GO:1900126 [negative regulation of hyaluronan biosynthetic process]
GO:1903077 [negative regulation of protein localization to plasma membrane]
GO:1903561 [extracellular vesicle]
Show all
 1675 aa
191.6 kDa 		No 0
CLTC-002
ENSP00000376763
ENST00000393043
Q00610 [Direct mapping]
Clathrin heavy chain 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003725 [double-stranded RNA binding]
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007067 [mitotic nuclear division]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030118 [clathrin coat]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
GO:0030136 [clathrin-coated vesicle]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0032051 [clathrin light chain binding]
GO:0032588 [trans-Golgi network membrane]
GO:0033572 [transferrin transport]
GO:0036020 [endolysosome membrane]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042470 [melanosome]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071439 [clathrin complex]
GO:1900126 [negative regulation of hyaluronan biosynthetic process]
GO:1903077 [negative regulation of protein localization to plasma membrane]
GO:1903561 [extracellular vesicle]
Show all
 1639 aa
187.9 kDa 		No 0
CLTC-008
ENSP00000465200
ENST00000472651
K7EJJ5 [Direct mapping]
Clathrin heavy chain 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
Show all
 222 aa
25.7 kDa 		No 0
CLTC-009
ENSP00000461977
ENST00000475458
J3KRF5 [Direct mapping]
Clathrin heavy chain 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
Show all
 131 aa
15.5 kDa 		No 0
CLTC-010
ENSP00000462252
ENST00000579456
J3KS13 [Direct mapping]
Clathrin heavy chain 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005737 [cytoplasm]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 612 aa
70.7 kDa 		No 0
CLTC-014
ENSP00000462592
ENST00000580081
J3KSQ2 [Direct mapping]
Clathrin heavy chain 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
Show all
 122 aa
13.7 kDa 		No 0
CLTC-201
ENSP00000479606
ENST00000621829
A0A087WVQ6 [Direct mapping]
Clathrin heavy chain
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0019901 [protein kinase binding]
GO:0030117 [membrane coat]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
GO:0043209 [myelin sheath]
Show all
 1679 aa
192.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.