Cell atlas - WRAP53 - The Human Protein Atlas

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WRAP53

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	WRAP53
Gene description	WD repeat containing, antisense to TP53
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies. In addition localized to the cytosol & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (validated)
Additional location	In addition localized to the Nucleoplasm (approved), Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA023026 , HPA029928
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies. In addition localized to the cytosol & nucleoplasm.

Main location

Nuclear bodies (validated)

Additional location

Nucleoplasm (approved), Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA023026	A-431	Nuclear bodies
HPA023026	U-2 OS	Nucleoplasm
HPA023026	U-2 OS	Cytosol
HPA023026	U-251 MG	Nucleoplasm
		Nuclear bodies
		Cytosol
HPA029928	A-431	Nucleoplasm
HPA029928	A-431	Nuclear bodies
HPA029928	U-2 OS	Nucleoplasm
HPA029928	U-2 OS	Cytosol
HPA029928	U-251 MG	Nuclear bodies

GENE INFORMATION
Gene name	WRAP53 (HGNC Symbol)
Synonyms	FLJ10385, TCAB1, WDR79
Description	WD repeat containing, antisense to TP53 (HGNC Symbol)
Entrez gene summary	This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7686071 - 7703502
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141499 (version 83.38)
Entrez gene	55135
UniProt	Q9BUR4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUR4
Antibodypedia	WRAP53 antibodies

PROTEIN BROWSER

WRAP53-001	WRAP53-002	WRAP53-008	WRAP53-009	WRAP53-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WRAP53-001 ENSP00000324203 ENST00000316024	Q9BUR4 [Direct mapping] Telomerase Cajal body protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005697 [telomerase holoenzyme complex] GO:0005737 [cytoplasm] GO:0015030 [Cajal body] GO:0032203 [telomere formation via telomerase] GO:0051973 [positive regulation of telomerase activity] Show all	548 aa 59.3 kDa	No	0
WRAP53-002 ENSP00000379727 ENST00000396463	Q9BUR4 [Direct mapping] Telomerase Cajal body protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005697 [telomerase holoenzyme complex] GO:0005737 [cytoplasm] GO:0015030 [Cajal body] GO:0032203 [telomere formation via telomerase] GO:0051973 [positive regulation of telomerase activity] Show all	548 aa 59.3 kDa	No	0
WRAP53-008 ENSP00000397219 ENST00000431639	Q9BUR4 [Direct mapping] Telomerase Cajal body protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005697 [telomerase holoenzyme complex] GO:0005737 [cytoplasm] GO:0015030 [Cajal body] GO:0032203 [telomere formation via telomerase] GO:0051973 [positive regulation of telomerase activity] Show all	548 aa 59.3 kDa	No	0
WRAP53-009 ENSP00000411061 ENST00000457584	Q9BUR4 [Direct mapping] Telomerase Cajal body protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005697 [telomerase holoenzyme complex] GO:0005737 [cytoplasm] GO:0015030 [Cajal body] GO:0032203 [telomere formation via telomerase] GO:0051973 [positive regulation of telomerase activity] Show all	548 aa 59.3 kDa	No	0
WRAP53-010 ENSP00000434999 ENST00000534050	E9PMG4 [Direct mapping] Telomerase Cajal body protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	515 aa 55.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.