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WRAP53

GENERAL INFORMATION

Gene name

 WRAP53

Gene description

 WD repeat containing, antisense to TP53

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA023026 , HPA028130
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and pancreatic cancer (favourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA023026
HPA028130

GENE INFORMATION

Gene name

 WRAP53 (HGNC Symbol)

Synonyms

 FLJ10385, TCAB1, WDR79

Description

 WD repeat containing, antisense to TP53 (HGNC Symbol)

Entrez gene summary

 This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7686071 - 7703502

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141499 (version 83.38)

Entrez gene

 55135

UniProt

 Q9BUR4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BUR4

Antibodypedia

 WRAP53 antibodies

PROTEIN BROWSER
WRAP53-001
WRAP53-002
WRAP53-008
WRAP53-009
WRAP53-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WRAP53-001
ENSP00000324203
ENST00000316024
Q9BUR4 [Direct mapping]
Telomerase Cajal body protein 1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005737 [cytoplasm]
GO:0015030 [Cajal body]
GO:0032203 [telomere formation via telomerase]
GO:0051973 [positive regulation of telomerase activity]
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 548 aa
59.3 kDa 		No 0
WRAP53-002
ENSP00000379727
ENST00000396463
Q9BUR4 [Direct mapping]
Telomerase Cajal body protein 1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005737 [cytoplasm]
GO:0015030 [Cajal body]
GO:0032203 [telomere formation via telomerase]
GO:0051973 [positive regulation of telomerase activity]
Show all
 548 aa
59.3 kDa 		No 0
WRAP53-008
ENSP00000397219
ENST00000431639
Q9BUR4 [Direct mapping]
Telomerase Cajal body protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005737 [cytoplasm]
GO:0015030 [Cajal body]
GO:0032203 [telomere formation via telomerase]
GO:0051973 [positive regulation of telomerase activity]
Show all
 548 aa
59.3 kDa 		No 0
WRAP53-009
ENSP00000411061
ENST00000457584
Q9BUR4 [Direct mapping]
Telomerase Cajal body protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005737 [cytoplasm]
GO:0015030 [Cajal body]
GO:0032203 [telomere formation via telomerase]
GO:0051973 [positive regulation of telomerase activity]
Show all
 548 aa
59.3 kDa 		No 0
WRAP53-010
ENSP00000434999
ENST00000534050
E9PMG4 [Direct mapping]
Telomerase Cajal body protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 515 aa
55.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.