Cell atlas - CARD14 - The Human Protein Atlas

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CARD14

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CARD14
Gene description	Caspase recruitment domain family, member 14
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (T-47d, SK-BR-3, MCF7)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, SK-BR-3, MCF7) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CARD14 (HGNC Symbol)
Synonyms	BIMP2, CARMA2, PSORS2
Description	Caspase recruitment domain family, member 14 (HGNC Symbol)
Entrez gene summary	This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	80169992 - 80209331
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141527 (version 83.38)
Entrez gene	79092
UniProt	Q9BXL6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXL6
Antibodypedia	CARD14 antibodies

PROTEIN BROWSER

CARD14-001	CARD14-009	CARD14-011	CARD14-016	CARD14-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CARD14-001 ENSP00000458715 ENST00000573882	Q9BXL6 [Direct mapping] Caspase recruitment domain-containing protein 14 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0050700 [CARD domain binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	1004 aa 113.3 kDa	No	0
CARD14-009 ENSP00000461447 ENST00000576785	I3L4Q8 [Direct mapping] Caspase recruitment domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		44 aa 5.3 kDa	No	0
CARD14-011 ENSP00000459244 ENST00000575465	I3L1Z7 [Direct mapping] Caspase recruitment domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042981 [regulation of apoptotic process] Show all	70 aa 8.2 kDa	No	0
CARD14-016 ENSP00000461806 ENST00000570421	Q9BXL6 [Direct mapping] Caspase recruitment domain-containing protein 14 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0050700 [CARD domain binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	740 aa 83.7 kDa	No	0
CARD14-201 ENSP00000344549 ENST00000344227	Q9BXL6 [Direct mapping] Caspase recruitment domain-containing protein 14 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0050700 [CARD domain binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	1004 aa 113.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.