Tissue expression of CARD14 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CARD14
Gene description	Caspase recruitment domain family, member 14
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (skin)
GTEx:	Tissue enhanced (skin)
FANTOM5:	Not detected

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skin)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	CARD14 (HGNC Symbol)
Synonyms	BIMP2, CARMA2, PSORS2
Description	Caspase recruitment domain family, member 14 (HGNC Symbol)
Entrez gene summary	This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	80169992 - 80209331
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141527 (version 83.38)
Entrez gene	79092
UniProt	Q9BXL6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXL6
Antibodypedia	CARD14 antibodies

PROTEIN BROWSER

CARD14-001	CARD14-009	CARD14-011	CARD14-016	CARD14-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CARD14-001 ENSP00000458715 ENST00000573882	Q9BXL6 [Direct mapping] Caspase recruitment domain-containing protein 14 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0050700 [CARD domain binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	1004 aa 113.3 kDa	No	0
CARD14-009 ENSP00000461447 ENST00000576785	I3L4Q8 [Direct mapping] Caspase recruitment domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		44 aa 5.3 kDa	No	0
CARD14-011 ENSP00000459244 ENST00000575465	I3L1Z7 [Direct mapping] Caspase recruitment domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042981 [regulation of apoptotic process] Show all	70 aa 8.2 kDa	No	0
CARD14-016 ENSP00000461806 ENST00000570421	Q9BXL6 [Direct mapping] Caspase recruitment domain-containing protein 14 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0050700 [CARD domain binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	740 aa 83.7 kDa	No	0
CARD14-201 ENSP00000344549 ENST00000344227	Q9BXL6 [Direct mapping] Caspase recruitment domain-containing protein 14 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0050700 [CARD domain binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	1004 aa 113.3 kDa	No	0