Cell atlas - FN3KRP - The Human Protein Atlas

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FN3KRP

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FN3KRP
Gene description	Fructosamine 3 kinase related protein
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Mouse	Localized to the Nucleus, Golgi apparatus in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA056172
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056172	A-431	Nucleoplasm
	HPA056172	U-2 OS	No staining
	HPA056172	U-251 MG	Nucleoplasm

MOUSE CELLS

Main location

Nucleus, Golgi apparatus

Mouse gene

ENSMUSG00000039253 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA056172	NIH 3T3	Nucleus
	HPA056172	NIH 3T3	Golgi apparatus

GENE INFORMATION
Gene name	FN3KRP (HGNC Symbol)
Synonyms	FLJ12171, FN3KL
Description	Fructosamine 3 kinase related protein (HGNC Symbol)
Entrez gene summary	A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	82716683 - 82730328
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141560 (version 83.38)
Entrez gene	79672
UniProt	Q9HA64 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HA64
Antibodypedia	FN3KRP antibodies

PROTEIN BROWSER

FN3KRP-001	FN3KRP-006	FN3KRP-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FN3KRP-001 ENSP00000269373 ENST00000269373	Q9HA64 [Direct mapping] Ketosamine-3-kinase Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	309 aa 34.4 kDa	No	0
FN3KRP-006 ENSP00000459653 ENST00000577128	I3L2G3 [Direct mapping] Ketosamine-3-kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	127 aa 14.1 kDa	No	0
FN3KRP-007 ENSP00000460243 ENST00000573158	I3L378 [Direct mapping] Ketosamine-3-kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	125 aa 14 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.