Expression of FN3KRP in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

FN3KRP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FN3KRP
Gene description	Fructosamine 3 kinase related protein
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA065831
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable).
Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA065831

GENE INFORMATION
Gene name	FN3KRP (HGNC Symbol)
Synonyms	FLJ12171, FN3KL
Description	Fructosamine 3 kinase related protein (HGNC Symbol)
Entrez gene summary	A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	82716683 - 82730328
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141560 (version 83.38)
Entrez gene	79672
UniProt	Q9HA64 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HA64
Antibodypedia	FN3KRP antibodies

PROTEIN BROWSER

FN3KRP-001	FN3KRP-006	FN3KRP-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FN3KRP-001 ENSP00000269373 ENST00000269373	Q9HA64 [Direct mapping] Ketosamine-3-kinase Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	309 aa 34.4 kDa	No	0
FN3KRP-006 ENSP00000459653 ENST00000577128	I3L2G3 [Direct mapping] Ketosamine-3-kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	127 aa 14.1 kDa	No	0
FN3KRP-007 ENSP00000460243 ENST00000573158	I3L378 [Direct mapping] Ketosamine-3-kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	125 aa 14 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.