Fields »
ABOUT
HELP
BLOG
GRB7

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 GRB7

Gene description

 Growth factor receptor-bound protein 7

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane.

RNA cell category

 Cell line enriched (SK-BR-3)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB073538
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SK-BR-3)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane.

Main location

 Plasma membrane (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB073538 HeLa Plasma membrane
Cytosol
CAB073538 MCF7 Cytosol Intensity
CAB073538 U-2 OS Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 GRB7

Synonyms

Description

 Growth factor receptor-bound protein 7 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 39737927 - 39747291

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141738 (version 83.38)

Entrez gene

 2886

UniProt

 Q14451 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14451

Antibodypedia

 GRB7 antibodies

PROTEIN BROWSER
GRB7-001
GRB7-002
GRB7-003
GRB7-006
GRB7-009
GRB7-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRB7-001
ENSP00000310771
ENST00000309156
Q14451 [Direct mapping]
Growth factor receptor-bound protein 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009967 [positive regulation of signal transduction]
GO:0010494 [cytoplasmic stress granule]
GO:0017148 [negative regulation of translation]
GO:0019901 [protein kinase binding]
GO:0030335 [positive regulation of cell migration]
GO:0034063 [stress granule assembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0050900 [leukocyte migration]
Show all
 532 aa
59.7 kDa 		No 0
GRB7-002
ENSP00000377761
ENST00000394211
Q14451 [Direct mapping]
Growth factor receptor-bound protein 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009967 [positive regulation of signal transduction]
GO:0010494 [cytoplasmic stress granule]
GO:0017148 [negative regulation of translation]
GO:0019901 [protein kinase binding]
GO:0030335 [positive regulation of cell migration]
GO:0034063 [stress granule assembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0050900 [leukocyte migration]
Show all
 532 aa
59.7 kDa 		No 0
GRB7-003
ENSP00000377754
ENST00000394204
Q14451 [Direct mapping]
Growth factor receptor-bound protein 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009967 [positive regulation of signal transduction]
GO:0010494 [cytoplasmic stress granule]
GO:0017148 [negative regulation of translation]
GO:0019901 [protein kinase binding]
GO:0030335 [positive regulation of cell migration]
GO:0034063 [stress granule assembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0050900 [leukocyte migration]
Show all
 447 aa
49.4 kDa 		No 0
GRB7-006
ENSP00000403459
ENST00000445327
Q14451 [Direct mapping]
Growth factor receptor-bound protein 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009967 [positive regulation of signal transduction]
GO:0010494 [cytoplasmic stress granule]
GO:0017148 [negative regulation of translation]
GO:0019901 [protein kinase binding]
GO:0030335 [positive regulation of cell migration]
GO:0034063 [stress granule assembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0050900 [leukocyte migration]
Show all
 555 aa
62.1 kDa 		No 0
GRB7-009
ENSP00000377759
ENST00000394209
Q14451 [Direct mapping]
Growth factor receptor-bound protein 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009967 [positive regulation of signal transduction]
GO:0010494 [cytoplasmic stress granule]
GO:0017148 [negative regulation of translation]
GO:0019901 [protein kinase binding]
GO:0030335 [positive regulation of cell migration]
GO:0034063 [stress granule assembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0050900 [leukocyte migration]
Show all
 532 aa
59.7 kDa 		No 0
GRB7-011
ENSP00000463416
ENST00000577695
J3QL76 [Direct mapping]
Growth factor receptor-bound protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 118 aa
12.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.