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TXNL4A

GENERAL INFORMATION

Gene name

 TXNL4A

Gene description

 Thioredoxin-like 4A

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TXNL4A (HGNC Symbol)

Synonyms

 DIB1, DIM1, HsT161, SNRNP15, TXNL4, U5-15kD

Description

 Thioredoxin-like 4A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Chromosome

 18

Cytoband

 q23

Chromosome location (bp)

 79970811 - 80033949

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141759 (version 83.38)

Entrez gene

 10907

UniProt

 P83876 (UniProt - Evidence at protein level)

neXtProt

 NX_P83876

Antibodypedia

 TXNL4A antibodies

PROTEIN BROWSER
TXNL4A-001
TXNL4A-002
TXNL4A-004
TXNL4A-007
TXNL4A-010
TXNL4A-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TXNL4A-001
ENSP00000269601
ENST00000269601
P83876 [Direct mapping]
Thioredoxin-like protein 4A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0007067 [mitotic nuclear division]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0051301 [cell division]
Show all
 142 aa
16.8 kDa 		No 0
TXNL4A-002
ENSP00000465572
ENST00000585474
K7ESL1 [Direct mapping]
Thioredoxin-like protein 4A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
Show all
 71 aa
8.5 kDa 		No 0
TXNL4A-004
ENSP00000465493
ENST00000592957
K7ESL1 [Direct mapping]
Thioredoxin-like protein 4A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
Show all
 71 aa
8.5 kDa 		No 0
TXNL4A-007
ENSP00000468493
ENST00000591711
K7ES07 [Direct mapping]
Thioredoxin-like protein 4A
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   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
Show all
 103 aa
12.2 kDa 		No 0
TXNL4A-010
ENSP00000465321
ENST00000588162
K7EJU2 [Direct mapping]
Thioredoxin-like protein 4A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
Show all
 57 aa
6.8 kDa 		No 0
TXNL4A-012
ENSP00000468761
ENST00000592837
K7ESL1 [Direct mapping]
Thioredoxin-like protein 4A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
Show all
 71 aa
8.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.