Tissue expression of TXNL4A - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TXNL4A
Gene description	Thioredoxin-like 4A
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TXNL4A (HGNC Symbol)
Synonyms	DIB1, DIM1, HsT161, SNRNP15, TXNL4, U5-15kD
Description	Thioredoxin-like 4A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Chromosome	18
Cytoband	q23
Chromosome location (bp)	79970811 - 80033949
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141759 (version 83.38)
Entrez gene	10907
UniProt	P83876 (UniProt - Evidence at protein level)
neXtProt	NX_P83876
Antibodypedia	TXNL4A antibodies

PROTEIN BROWSER

TXNL4A-001	TXNL4A-002	TXNL4A-004	TXNL4A-007	TXNL4A-010	TXNL4A-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TXNL4A-001 ENSP00000269601 ENST00000269601	P83876 [Direct mapping] Thioredoxin-like protein 4A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000245 [spliceosomal complex assembly] GO:0000375 [RNA splicing, via transesterification reactions] GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0005682 [U5 snRNP] GO:0007067 [mitotic nuclear division] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0046540 [U4/U6 x U5 tri-snRNP complex] GO:0051301 [cell division] Show all	142 aa 16.8 kDa	No	0
TXNL4A-002 ENSP00000465572 ENST00000585474	K7ESL1 [Direct mapping] Thioredoxin-like protein 4A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005681 [spliceosomal complex] GO:0005682 [U5 snRNP] GO:0046540 [U4/U6 x U5 tri-snRNP complex] Show all	71 aa 8.5 kDa	No	0
TXNL4A-004 ENSP00000465493 ENST00000592957	K7ESL1 [Direct mapping] Thioredoxin-like protein 4A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005681 [spliceosomal complex] GO:0005682 [U5 snRNP] GO:0046540 [U4/U6 x U5 tri-snRNP complex] Show all	71 aa 8.5 kDa	No	0
TXNL4A-007 ENSP00000468493 ENST00000591711	K7ES07 [Direct mapping] Thioredoxin-like protein 4A Show all	MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005681 [spliceosomal complex] GO:0005682 [U5 snRNP] GO:0046540 [U4/U6 x U5 tri-snRNP complex] Show all	103 aa 12.2 kDa	No	0
TXNL4A-010 ENSP00000465321 ENST00000588162	K7EJU2 [Direct mapping] Thioredoxin-like protein 4A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005681 [spliceosomal complex] GO:0005682 [U5 snRNP] GO:0046540 [U4/U6 x U5 tri-snRNP complex] Show all	57 aa 6.8 kDa	No	0
TXNL4A-012 ENSP00000468761 ENST00000592837	K7ESL1 [Direct mapping] Thioredoxin-like protein 4A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005681 [spliceosomal complex] GO:0005682 [U5 snRNP] GO:0046540 [U4/U6 x U5 tri-snRNP complex] Show all	71 aa 8.5 kDa	No	0