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MVB12A

GENERAL INFORMATION

Gene name

 MVB12A

Gene description

 Multivesicular body subunit 12A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA041885 , HPA042231
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041885
HPA042231

GENE INFORMATION

Gene name

 MVB12A (HGNC Symbol)

Synonyms

 FAM125A, FLJ32495

Description

 Multivesicular body subunit 12A (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 17405722 - 17433724

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141971 (version 83.38)

Entrez gene

 93343

UniProt

 Q96EY5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96EY5

Antibodypedia

 MVB12A antibodies

PROTEIN BROWSER
MVB12A-001
MVB12A-007
MVB12A-008
MVB12A-009
MVB12A-012
MVB12A-016
MVB12A-017
MVB12A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MVB12A-001
ENSP00000324810
ENST00000317040
Q96EY5 [Direct mapping]
Multivesicular body subunit 12A
A0A024R7L6 [Target identity:100%; Query identity:100%]
Uncharacterized protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000813 [ESCRT I complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0008289 [lipid binding]
GO:0015031 [protein transport]
GO:0016235 [aggresome]
GO:0017124 [SH3 domain binding]
GO:0019075 [virus maturation]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0043130 [ubiquitin binding]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048524 [positive regulation of viral process]
GO:0070062 [extracellular exosome]
GO:1903772 [regulation of viral budding via host ESCRT complex]
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 273 aa
28.8 kDa 		No 0
MVB12A-007
ENSP00000433677
ENST00000528515
E9PJW8 [Direct mapping]
Multivesicular body subunit 12A
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 199 aa
20.8 kDa 		No 0
MVB12A-008
ENSP00000432526
ENST00000529939
E9PQA6 [Direct mapping]
Multivesicular body subunit 12A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0016235 [aggresome]
GO:0043231 [intracellular membrane-bounded organelle]
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 273 aa
28.7 kDa 		No 0
MVB12A-009
ENSP00000433280
ENST00000528911
E9PLL0 [Direct mapping]
Multivesicular body subunit 12A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 121 aa
13 kDa 		No 0
MVB12A-012
ENSP00000435052
ENST00000528604
E9PLZ8 [Direct mapping]
Multivesicular body subunit 12A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 134 aa
14.4 kDa 		No 0
MVB12A-016
ENSP00000472288
ENST00000600514
E9PLL0 [Direct mapping]
Multivesicular body subunit 12A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 121 aa
13 kDa 		No 0
MVB12A-017
ENSP00000470611
ENST00000594784
M0QZK6 [Direct mapping]
Multivesicular body subunit 12A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 122 aa
13.1 kDa 		No 0
MVB12A-201
ENSP00000444653
ENST00000543795
Q96EY5 [Direct mapping]
Multivesicular body subunit 12A
A0A024R7L6 [Target identity:100%; Query identity:100%]
Uncharacterized protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000813 [ESCRT I complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0008289 [lipid binding]
GO:0015031 [protein transport]
GO:0016235 [aggresome]
GO:0017124 [SH3 domain binding]
GO:0019075 [virus maturation]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0043130 [ubiquitin binding]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048524 [positive regulation of viral process]
GO:0070062 [extracellular exosome]
GO:1903772 [regulation of viral budding via host ESCRT complex]
Show all
 273 aa
28.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.