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CAPN10

GENERAL INFORMATION

Gene name

 CAPN10

Gene description

 Calpain 10

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular a pattern in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining in cells/structures not annotated, view images. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA004170
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (favourable) and head and neck cancer (favourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004170

GENE INFORMATION

Gene name

 CAPN10

Synonyms

Description

 Calpain 10 (HGNC Symbol)

Entrez gene summary

 Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 240586716 - 240617705

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142330 (version 83.38)

Entrez gene

 11132

UniProt

 Q9HC96 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HC96

Antibodypedia

 CAPN10 antibodies

PROTEIN BROWSER
CAPN10-001
CAPN10-002
CAPN10-005
CAPN10-006
CAPN10-007
CAPN10-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAPN10-001
ENSP00000375844
ENST00000391984
Q9HC96 [Direct mapping]
Calpain-10
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Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000149 [SNARE binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008092 [cytoskeletal protein binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032024 [positive regulation of insulin secretion]
GO:0032388 [positive regulation of intracellular transport]
GO:0032869 [cellular response to insulin stimulus]
GO:0046326 [positive regulation of glucose import]
GO:0097050 [type B pancreatic cell apoptotic process]
GO:2000676 [positive regulation of type B pancreatic cell apoptotic process]
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 672 aa
75 kDa 		No 0
CAPN10-002
ENSP00000289381
ENST00000352879
Q9HC96 [Direct mapping]
Calpain-10
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000149 [SNARE binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008092 [cytoskeletal protein binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032024 [positive regulation of insulin secretion]
GO:0032388 [positive regulation of intracellular transport]
GO:0032869 [cellular response to insulin stimulus]
GO:0046326 [positive regulation of glucose import]
GO:0097050 [type B pancreatic cell apoptotic process]
Show all
 138 aa
15.3 kDa 		No 0
CAPN10-005
ENSP00000384422
ENST00000404753
B7WPF5 [Direct mapping]
Calpain-10
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Predicted intracellular proteins
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0032869 [cellular response to insulin stimulus]
Show all
 653 aa
72.9 kDa 		No 0
CAPN10-006
ENSP00000270364
ENST00000270364
Q9HC96 [Direct mapping]
Calpain-10
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000149 [SNARE binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008092 [cytoskeletal protein binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032024 [positive regulation of insulin secretion]
GO:0032388 [positive regulation of intracellular transport]
GO:0032869 [cellular response to insulin stimulus]
GO:0046326 [positive regulation of glucose import]
GO:0097050 [type B pancreatic cell apoptotic process]
Show all
 139 aa
15.6 kDa 		No 0
CAPN10-007
ENSP00000270362
ENST00000354082
Q9HC96 [Direct mapping]
Calpain-10
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000149 [SNARE binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008092 [cytoskeletal protein binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032024 [positive regulation of insulin secretion]
GO:0032388 [positive regulation of intracellular transport]
GO:0032869 [cellular response to insulin stimulus]
GO:0046326 [positive regulation of glucose import]
GO:0097050 [type B pancreatic cell apoptotic process]
Show all
 517 aa
58 kDa 		No 0
CAPN10-017
ENSP00000407090
ENST00000432084
H7C2P1 [Direct mapping]
Calpain-10
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Predicted intracellular proteins
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0032869 [cellular response to insulin stimulus]
Show all
 85 aa
9.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.