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CAPN10

GENERAL INFORMATION

Gene name

 CAPN10

Gene description

 Calpain 10

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with a granular a pattern in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining in cells/structures not annotated, view images. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA004170
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CAPN10

Synonyms

Description

 Calpain 10 (HGNC Symbol)

Entrez gene summary

 Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 240586716 - 240617705

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142330 (version 83.38)

Entrez gene

 11132

UniProt

 Q9HC96 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HC96

Antibodypedia

 CAPN10 antibodies

PROTEIN BROWSER
CAPN10-001
CAPN10-002
CAPN10-005
CAPN10-006
CAPN10-007
CAPN10-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAPN10-001
ENSP00000375844
ENST00000391984
Q9HC96 [Direct mapping]
Calpain-10
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000149 [SNARE binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008092 [cytoskeletal protein binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032024 [positive regulation of insulin secretion]
GO:0032388 [positive regulation of intracellular transport]
GO:0032869 [cellular response to insulin stimulus]
GO:0046326 [positive regulation of glucose import]
GO:0097050 [type B pancreatic cell apoptotic process]
GO:2000676 [positive regulation of type B pancreatic cell apoptotic process]
Show all
 672 aa
75 kDa 		No 0
CAPN10-002
ENSP00000289381
ENST00000352879
Q9HC96 [Direct mapping]
Calpain-10
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000149 [SNARE binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008092 [cytoskeletal protein binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032024 [positive regulation of insulin secretion]
GO:0032388 [positive regulation of intracellular transport]
GO:0032869 [cellular response to insulin stimulus]
GO:0046326 [positive regulation of glucose import]
GO:0097050 [type B pancreatic cell apoptotic process]
Show all
 138 aa
15.3 kDa 		No 0
CAPN10-005
ENSP00000384422
ENST00000404753
B7WPF5 [Direct mapping]
Calpain-10
Show all
Predicted intracellular proteins
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0032869 [cellular response to insulin stimulus]
Show all
 653 aa
72.9 kDa 		No 0
CAPN10-006
ENSP00000270364
ENST00000270364
Q9HC96 [Direct mapping]
Calpain-10
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000149 [SNARE binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008092 [cytoskeletal protein binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032024 [positive regulation of insulin secretion]
GO:0032388 [positive regulation of intracellular transport]
GO:0032869 [cellular response to insulin stimulus]
GO:0046326 [positive regulation of glucose import]
GO:0097050 [type B pancreatic cell apoptotic process]
Show all
 139 aa
15.6 kDa 		No 0
CAPN10-007
ENSP00000270362
ENST00000354082
Q9HC96 [Direct mapping]
Calpain-10
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000149 [SNARE binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008092 [cytoskeletal protein binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032024 [positive regulation of insulin secretion]
GO:0032388 [positive regulation of intracellular transport]
GO:0032869 [cellular response to insulin stimulus]
GO:0046326 [positive regulation of glucose import]
GO:0097050 [type B pancreatic cell apoptotic process]
Show all
 517 aa
58 kDa 		No 0
CAPN10-017
ENSP00000407090
ENST00000432084
H7C2P1 [Direct mapping]
Calpain-10
Show all
Predicted intracellular proteins
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0032869 [cellular response to insulin stimulus]
Show all
 85 aa
9.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.