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Gene name

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Chromosome

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Reliability

Reliability

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Validation

Method

Validation

Method

Validation

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Searches

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Expression

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Cancer

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Detectable

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Detectable

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PSMB6
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PSMB6

Gene description

Proteasome subunit beta 6

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA023312
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA023312

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate cytoplasmic and nuclear positivity was observed in most cancer tissues. Strong immunoreactivity was observed in several cases of endometrial, testicular and liver cancers.

GENE INFORMATION

Gene name

PSMB6 (HGNC Symbol)

Synonyms

DELTA, Y

Description

Proteasome subunit beta 6 (HGNC Symbol)

Entrez gene summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Chromosome

17

Cytoband

p13.2

Chromosome location (bp)

4796144 - 4798503

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142507 (version 83.38)

Entrez gene

5694

UniProt

P28072 (UniProt - Evidence at protein level)

neXtProt

NX_P28072

Antibodypedia

PSMB6 antibodies

PROTEIN BROWSER

PSMB6-001
PSMB6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMB6-001
ENSP00000270586
ENST00000270586
P28072 [Direct mapping]
Proteasome subunit beta type-6
Q6IAT9 [Target identity:100%; Query identity:100%]
Proteasome subunit beta type
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Threonine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005839 [proteasome core complex]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
239 aa
25.4 kDa
No 0
PSMB6-201
ENSP00000485006
ENST00000614486
A0A087X2I4 [Direct mapping]
Proteasome subunit beta type
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005839 [proteasome core complex]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
213 aa
23.1 kDa
No 0

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