Expression of MMEL1 in cancer - Summary - The Human Protein Atlas

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MMEL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MMEL1
Gene description	Membrane metallo-endopeptidase-like 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, EFO-21, SK-BR-3)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 3 antibodies. HPA007876 , HPA008205 , CAB020786
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007876	HPA008205	CAB020786

GENE INFORMATION
Gene name	MMEL1 (HGNC Symbol)
Synonyms	MMEL2, NEPII, NL1, NL2, SEP
Description	Membrane metallo-endopeptidase-like 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.32
Chromosome location (bp)	2590639 - 2632990
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142606 (version 83.38)
Entrez gene	79258
UniProt	Q495T6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q495T6
Antibodypedia	MMEL1 antibodies

PROTEIN BROWSER

MMEL1-001	MMEL1-002	MMEL1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MMEL1-001 ENSP00000367668 ENST00000378412	Q495T6 [Direct mapping] Membrane metallo-endopeptidase-like 1 Membrane metallo-endopeptidase-like 1, soluble form Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	779 aa 89.4 kDa	No	0
MMEL1-002 ENSP00000461938 ENST00000471840	J3KRD2 [Direct mapping] Membrane metallo-endopeptidase-like 1 Show all	Predicted intracellular proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] Show all	66 aa 7.5 kDa	No	0
MMEL1-006 ENSP00000422492 ENST00000502556	Q495T6 [Direct mapping] Membrane metallo-endopeptidase-like 1 Membrane metallo-endopeptidase-like 1, soluble form Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	622 aa 71.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.