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Gene name

Class

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In atlas

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Reliability

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Searches

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Detectable

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EPHA2
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS

GENE/PROTEIN

Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

EPHA2

Gene description

EPH receptor A2

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Predicted membrane proteins
RAS pathway related proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (esophagus)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (esophagus)

Protein evidence

Evidence at protein level

DATA RELIABILITY

Reliability score

Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
N/A
Cerebral cortex
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Thyroid gland
N/A
Parathyroid gland
N/A
Adrenal gland
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Bone marrow
N/A
Lymph node
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Heart muscle
N/A
Skeletal muscle
N/A
Smooth muscle
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Gallbladder
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Salivary gland
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Small intestine
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
Prostate
N/A
Seminal vesicle
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
Endometrium
N/A
Fallopian tube
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Adipose tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW

Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)

GENE INFORMATION

Gene name

EPHA2 (HGNC Symbol)

Synonyms

ECK

Description

EPH receptor A2 (HGNC Symbol)

Entrez gene summary

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]

Chromosome

1

Cytoband

p36.13

Chromosome location (bp)

16124337 - 16156087

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142627 (version 83.38)

Entrez gene

1969

UniProt

P29317 (UniProt - Evidence at protein level)

neXtProt

NX_P29317

Antibodypedia

EPHA2 antibodies

PROTEIN BROWSER

EPHA2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EPHA2-001
ENSP00000351209
ENST00000358432
P29317 [Direct mapping]
Ephrin type-A receptor 2
A0A024QZA8 [Target identity:100%; Query identity:100%]
Receptor protein-tyrosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001525 [angiogenesis]
GO:0001568 [blood vessel development]
GO:0001570 [vasculogenesis]
GO:0001649 [osteoblast differentiation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0009986 [cell surface]
GO:0010591 [regulation of lamellipodium assembly]
GO:0014028 [notochord formation]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021915 [neural tube development]
GO:0030182 [neuron differentiation]
GO:0030216 [keratinocyte differentiation]
GO:0030316 [osteoclast differentiation]
GO:0031256 [leading edge membrane]
GO:0031258 [lamellipodium membrane]
GO:0032587 [ruffle membrane]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0036342 [post-anal tail morphogenesis]
GO:0043491 [protein kinase B signaling]
GO:0043535 [regulation of blood vessel endothelial cell migration]
GO:0045765 [regulation of angiogenesis]
GO:0046849 [bone remodeling]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048320 [axial mesoderm formation]
GO:0048570 [notochord morphogenesis]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060035 [notochord cell development]
GO:0060326 [cell chemotaxis]
GO:0060444 [branching involved in mammary gland duct morphogenesis]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070848 [response to growth factor]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090630 [activation of GTPase activity]
Show all
976 aa
108.3 kDa
Yes 1

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