Expression of MAP3K6 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MAP3K6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAP3K6
Gene description	Mitogen-activated protein kinase kinase kinase 6
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA051192
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable), head and neck cancer (favourable) and liver cancer (unfavourable).
Glioma p<0.001 Head and neck cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051192

GENE INFORMATION
Gene name	MAP3K6 (HGNC Symbol)
Synonyms	ASK2, MAPKKK6, MEKK6
Description	Mitogen-activated protein kinase kinase kinase 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	p36.11
Chromosome location (bp)	27355184 - 27366892
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142733 (version 83.38)
Entrez gene	9064
UniProt	O95382 (UniProt - Evidence at protein level)
neXtProt	NX_O95382
Antibodypedia	MAP3K6 antibodies

PROTEIN BROWSER

MAP3K6-001	MAP3K6-002	MAP3K6-006	MAP3K6-007	MAP3K6-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP3K6-001 ENSP00000419591 ENST00000493901	O95382 [Direct mapping] Mitogen-activated protein kinase kinase kinase 6 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000186 [activation of MAPKK activity] GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007257 [activation of JUN kinase activity] GO:0007346 [regulation of mitotic cell cycle] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0042981 [regulation of apoptotic process] Show all	1288 aa 142.6 kDa	No	0
MAP3K6-002 ENSP00000418731 ENST00000472410	H0Y894 [Direct mapping] Mitogen-activated protein kinase kinase kinase 6 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0042981 [regulation of apoptotic process] Show all	798 aa 88.7 kDa	No	0
MAP3K6-006 ENSP00000418932 ENST00000486046	H0Y8A3 [Direct mapping] Mitogen-activated protein kinase kinase kinase 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0007346 [regulation of mitotic cell cycle] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0042981 [regulation of apoptotic process] Show all	82 aa 9.1 kDa	No	0
MAP3K6-007 ENSP00000350195 ENST00000357582	O95382 [Direct mapping] Mitogen-activated protein kinase kinase kinase 6 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000186 [activation of MAPKK activity] GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007257 [activation of JUN kinase activity] GO:0007346 [regulation of mitotic cell cycle] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0042981 [regulation of apoptotic process] Show all	1288 aa 142.6 kDa	No	0
MAP3K6-008 ENSP00000363152 ENST00000374040	O95382 [Direct mapping] Mitogen-activated protein kinase kinase kinase 6 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000186 [activation of MAPKK activity] GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007257 [activation of JUN kinase activity] GO:0007346 [regulation of mitotic cell cycle] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0042981 [regulation of apoptotic process] Show all	1280 aa 141.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.