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Mitogen-activated protein kinase kinase kinase 6 (HGNC Symbol)
Entrez gene summary
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
O95382 [Direct mapping] Mitogen-activated protein kinase kinase kinase 6
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000186 [activation of MAPKK activity] GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007257 [activation of JUN kinase activity] GO:0007346 [regulation of mitotic cell cycle] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0042981 [regulation of apoptotic process]
H0Y8A3 [Direct mapping] Mitogen-activated protein kinase kinase kinase 6
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Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm] GO:0007346 [regulation of mitotic cell cycle] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0042981 [regulation of apoptotic process]
