Cell atlas - CELA3A - The Human Protein Atlas

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CELA3A

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	CELA3A
Gene description	Chymotrypsin-like elastase family, member 3A
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enriched (MOLT-4)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA028086
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (MOLT-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028086	A549	Cytosol
	HPA028086	U-2 OS	Cytosol

GENE INFORMATION
Gene name	CELA3A (HGNC Symbol)
Synonyms	ELA3, ELA3A
Description	Chymotrypsin-like elastase family, member 3A (HGNC Symbol)
Entrez gene summary	Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	22001656 - 22012539
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142789 (version 83.38)
Entrez gene	10136
UniProt	P09093 (UniProt - Evidence at protein level)
neXtProt	NX_P09093
Antibodypedia	CELA3A antibodies

PROTEIN BROWSER

CELA3A-001	CELA3A-002	CELA3A-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CELA3A-001 ENSP00000290122 ENST00000290122	P09093 [Direct mapping] Chymotrypsin-like elastase family member 3A Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0008203 [cholesterol metabolic process] Show all	270 aa 29.5 kDa	Yes	0
CELA3A-002 ENSP00000363795 ENST00000374663	B1AQ52 [Direct mapping] Chymotrypsin-like elastase family member 3A Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	121 aa 13.2 kDa	Yes	0
CELA3A-004 ENSP00000383130 ENST00000400271	B1AQ55 [Direct mapping] Chymotrypsin-like elastase family member 3A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	75 aa 8.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.