Expression of CELA3A in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CELA3A

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CELA3A
Gene description	Chymotrypsin-like elastase family, member 3A
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (pancreatic cancer)
HPA (cell line):	Cell line enriched (MOLT-4)
HPA (normal tissue):	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expressio in pancreas

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA045650
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045650

GENE INFORMATION
Gene name	CELA3A (HGNC Symbol)
Synonyms	ELA3, ELA3A
Description	Chymotrypsin-like elastase family, member 3A (HGNC Symbol)
Entrez gene summary	Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	22001656 - 22012539
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142789 (version 83.38)
Entrez gene	10136
UniProt	P09093 (UniProt - Evidence at protein level)
neXtProt	NX_P09093
Antibodypedia	CELA3A antibodies

PROTEIN BROWSER

CELA3A-001	CELA3A-002	CELA3A-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CELA3A-001 ENSP00000290122 ENST00000290122	P09093 [Direct mapping] Chymotrypsin-like elastase family member 3A Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0008203 [cholesterol metabolic process] Show all	270 aa 29.5 kDa	Yes	0
CELA3A-002 ENSP00000363795 ENST00000374663	B1AQ52 [Direct mapping] Chymotrypsin-like elastase family member 3A Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	121 aa 13.2 kDa	Yes	0
CELA3A-004 ENSP00000383130 ENST00000400271	B1AQ55 [Direct mapping] Chymotrypsin-like elastase family member 3A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	75 aa 8.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.