Expression of NBPF3 in cancer - Summary - The Human Protein Atlas

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NBPF3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NBPF3
Gene description	Neuroblastoma breakpoint family, member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BJ hTERT+)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in a subset of cells in seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Approved based on 5 antibodies. HPA042595 , HPA043692 , HPA044023 , HPA046971 , HPA058050
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042595	HPA043692	HPA044023	HPA046971	HPA058050

GENE INFORMATION
Gene name	NBPF3 (HGNC Symbol)
Synonyms	AE2
Description	Neuroblastoma breakpoint family, member 3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. DUF1220 copy number variations in human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, Feb 2013]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	21440128 - 21485005
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142794 (version 83.38)
Entrez gene	84224
UniProt	Q9H094 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H094
Antibodypedia	NBPF3 antibodies

PROTEIN BROWSER

NBPF3-002	NBPF3-011	NBPF3-012	NBPF3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NBPF3-002 ENSP00000340336 ENST00000342104	Q9H094 [Direct mapping] Neuroblastoma breakpoint family member 3 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	621 aa 71.6 kDa	No	0
NBPF3-011 ENSP00000316782 ENST00000318249	Q9H094 [Direct mapping] Neuroblastoma breakpoint family member 3 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	633 aa 73 kDa	No	0
NBPF3-012 ENSP00000415711 ENST00000454000	Q9H094 [Direct mapping] Neuroblastoma breakpoint family member 3 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	563 aa 65.1 kDa	No	0
NBPF3-201 ENSP00000484028 ENST00000619554	Q9H094 [Direct mapping] Neuroblastoma breakpoint family member 3 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	577 aa 67.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.