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PRKACB

GENERAL INFORMATION

Gene name

 PRKACB

Gene description

 Protein kinase, cAMP-dependent, catalytic, beta

Protein class

 Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 17
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 2 antibodies.
HPA029754 , CAB010363
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029754
CAB010363

GENE INFORMATION

Gene name

 PRKACB (HGNC Symbol)

Synonyms

 PKACb

Description

 Protein kinase, cAMP-dependent, catalytic, beta (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]

Chromosome

 1

Cytoband

 p31.1

Chromosome location (bp)

 84078062 - 84238498

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142875 (version 83.38)

Entrez gene

 5567

UniProt

 P22694 (UniProt - Evidence at protein level)

neXtProt

 NX_P22694

Antibodypedia

 PRKACB antibodies

PROTEIN BROWSER
«
PRKACB-001
PRKACB-002
PRKACB-003
PRKACB-004
PRKACB-005
PRKACB-007
PRKACB-008
PRKACB-009
PRKACB-010
PRKACB-011
PRKACB-012
PRKACB-013
PRKACB-201
PRKACB-202
PRKACB-203
PRKACB-204
PRKACB-205
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKACB-001
ENSP00000359723
ENST00000370689
P22694 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
B2RB89 [Target identity:100%; Query identity:100%]
Protein kinase, cAMP-dependent, catalytic, beta, isoform CRA_a; cAMP-dependent protein kinase catalytic subunit beta isoform 2; cDNA, FLJ95374, Homo sapiens protein kinase, cAMP-dependent, catalytic, beta(PRKACB), transcript variant 2, mRNA
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003091 [renal water homeostasis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019433 [triglyceride catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050796 [regulation of insulin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0097546 [ciliary base]
Show all
 351 aa
40.6 kDa 		No 0
PRKACB-002
ENSP00000359722
ENST00000370688
P22694 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003091 [renal water homeostasis]
GO:0004672 [protein kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019433 [triglyceride catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050796 [regulation of insulin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0097546 [ciliary base]
Show all
 257 aa
29.7 kDa 		No 0
PRKACB-003
ENSP00000359714
ENST00000370680
B1APG3 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 264 aa
30.5 kDa 		No 0
PRKACB-004
ENSP00000359719
ENST00000370685
P22694 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001843 [neural tube closure]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003091 [renal water homeostasis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019433 [triglyceride catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050796 [regulation of insulin secretion]
GO:0051447 [negative regulation of meiotic cell cycle]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070613 [regulation of protein processing]
GO:0071377 [cellular response to glucagon stimulus]
GO:0097338 [response to clozapine]
GO:0097546 [ciliary base]
GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning]
Show all
 398 aa
46.2 kDa 		No 0
PRKACB-005
ENSP00000378315
ENST00000394839
P22694 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003091 [renal water homeostasis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019433 [triglyceride catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050796 [regulation of insulin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0097546 [ciliary base]
Show all
 321 aa
37 kDa 		No 0
PRKACB-007
ENSP00000401252
ENST00000446538
P22694 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003091 [renal water homeostasis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019433 [triglyceride catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050796 [regulation of insulin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0097546 [ciliary base]
Show all
 358 aa
41.4 kDa 		No 0
PRKACB-008
ENSP00000359718
ENST00000370684
B1APF9 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 245 aa
28.5 kDa 		No 0
PRKACB-009
ENSP00000390906
ENST00000436133
B1APF7 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 186 aa
21.6 kDa 		No 0
PRKACB-010
ENSP00000392275
ENST00000432111
B1APF8 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 214 aa
24.9 kDa 		No 0
PRKACB-011
ENSP00000393654
ENST00000450730
B1APG0 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 206 aa
23.9 kDa 		No 0
PRKACB-012
ENSP00000397175
ENST00000413538
B1APG2 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 209 aa
24.3 kDa 		No 0
PRKACB-013
ENSP00000399326
ENST00000417530
B1APG1 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 197 aa
23.1 kDa 		No 0
PRKACB-201
ENSP00000359716
ENST00000370682
P22694 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003091 [renal water homeostasis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019433 [triglyceride catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050796 [regulation of insulin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0097546 [ciliary base]
Show all
 355 aa
41 kDa 		No 0
PRKACB-202
ENSP00000378314
ENST00000394838
A0A0A0MS54 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 357 aa
41.3 kDa 		No 0
PRKACB-203
ENSP00000479339
ENST00000610457
A0A087WVC4 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 338 aa
39.2 kDa 		No 0
PRKACB-204
ENSP00000481980
ENST00000610703
P22694 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003091 [renal water homeostasis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019433 [triglyceride catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050796 [regulation of insulin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0097546 [ciliary base]
Show all
 339 aa
39.5 kDa 		No 0
PRKACB-205
ENSP00000479722
ENST00000614872
P22694 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003091 [renal water homeostasis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019433 [triglyceride catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050796 [regulation of insulin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0097546 [ciliary base]
Show all
 357 aa
41.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.