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KIF2C

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GENERAL INFORMATION

Gene name

 KIF2C

Gene description

 Kinesin family member 2C

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the centrosome & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Centrosome (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by custom assay

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA006219
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ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the centrosome & nucleoplasm.

Main location

 Nucleoplasm (supported), Centrosome (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA006219 RH-30 Nucleoplasm
Centrosome
Cytosol
HPA006219 SiHa Nucleoplasm
Centrosome
Cytosol
HPA006219 U-2 OS Nucleoplasm Intensity Intensity
Centrosome
Cytosol Intensity Intensity

CUSTOM DATA

 

 

 
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Thumbnail

Antibody

Cell line

Assay

Description
HPA006219 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. KIF2C is mostly expressed at the G1/S checkpoint, and during S and/or G2.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to custom assay

Intensity variation

 Nucleoplasm

GENE INFORMATION

Gene name

 KIF2C (HGNC Symbol)

Synonyms

 CT139, KNSL6, MCAK

Description

 Kinesin family member 2C (HGNC Symbol)

Entrez gene summary

 This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 44739818 - 44767767

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142945 (version 83.38)

Entrez gene

 11004

UniProt

 Q99661 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99661

Antibodypedia

 KIF2C antibodies

PROTEIN BROWSER
KIF2C-001
KIF2C-002
KIF2C-003
KIF2C-004
KIF2C-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF2C-001
ENSP00000361298
ENST00000372224
Q99661 [Direct mapping]
Kinesin-like protein KIF2C
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005881 [cytoplasmic microtubule]
GO:0007018 [microtubule-based movement]
GO:0007019 [microtubule depolymerization]
GO:0007067 [mitotic nuclear division]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0019237 [centromeric DNA binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030951 [establishment or maintenance of microtubule cytoskeleton polarity]
GO:0035371 [microtubule plus-end]
GO:0051010 [microtubule plus-end binding]
GO:0051301 [cell division]
GO:0051983 [regulation of chromosome segregation]
Show all
 725 aa
81.3 kDa 		No 0
KIF2C-002
ENSP00000361291
ENST00000372217
Q99661 [Direct mapping]
Kinesin-like protein KIF2C
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005881 [cytoplasmic microtubule]
GO:0007018 [microtubule-based movement]
GO:0007019 [microtubule depolymerization]
GO:0007067 [mitotic nuclear division]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0019237 [centromeric DNA binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030951 [establishment or maintenance of microtubule cytoskeleton polarity]
GO:0035371 [microtubule plus-end]
GO:0051010 [microtubule plus-end binding]
GO:0051301 [cell division]
GO:0051983 [regulation of chromosome segregation]
Show all
 671 aa
75.6 kDa 		No 0
KIF2C-003
ENSP00000410346
ENST00000452259
Q5JR91 [Direct mapping]
Kinesin-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 336 aa
37.9 kDa 		No 0
KIF2C-004
ENSP00000395050
ENST00000455186
Q5JR89 [Direct mapping]
Kinesin-like protein KIF2C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 287 aa
32.4 kDa 		No 0
KIF2C-006
ENSP00000402172
ENST00000423289
H0Y5Z9 [Direct mapping]
Kinesin-like protein KIF2C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 107 aa
11.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.