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KIF2C

GENERAL INFORMATION

Gene name

 KIF2C

Gene description

 Kinesin family member 2C

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 KIF2C (HGNC Symbol)

Synonyms

 CT139, KNSL6, MCAK

Description

 Kinesin family member 2C (HGNC Symbol)

Entrez gene summary

 This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 44739818 - 44767767

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142945 (version 83.38)

Entrez gene

 11004

UniProt

 Q99661 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99661

Antibodypedia

 KIF2C antibodies

PROTEIN BROWSER
KIF2C-001
KIF2C-002
KIF2C-003
KIF2C-004
KIF2C-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF2C-001
ENSP00000361298
ENST00000372224
Q99661 [Direct mapping]
Kinesin-like protein KIF2C
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005881 [cytoplasmic microtubule]
GO:0007018 [microtubule-based movement]
GO:0007019 [microtubule depolymerization]
GO:0007067 [mitotic nuclear division]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0019237 [centromeric DNA binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030951 [establishment or maintenance of microtubule cytoskeleton polarity]
GO:0035371 [microtubule plus-end]
GO:0051010 [microtubule plus-end binding]
GO:0051301 [cell division]
GO:0051983 [regulation of chromosome segregation]
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 725 aa
81.3 kDa 		No 0
KIF2C-002
ENSP00000361291
ENST00000372217
Q99661 [Direct mapping]
Kinesin-like protein KIF2C
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005881 [cytoplasmic microtubule]
GO:0007018 [microtubule-based movement]
GO:0007019 [microtubule depolymerization]
GO:0007067 [mitotic nuclear division]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0019237 [centromeric DNA binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030951 [establishment or maintenance of microtubule cytoskeleton polarity]
GO:0035371 [microtubule plus-end]
GO:0051010 [microtubule plus-end binding]
GO:0051301 [cell division]
GO:0051983 [regulation of chromosome segregation]
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 671 aa
75.6 kDa 		No 0
KIF2C-003
ENSP00000410346
ENST00000452259
Q5JR91 [Direct mapping]
Kinesin-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
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 336 aa
37.9 kDa 		No 0
KIF2C-004
ENSP00000395050
ENST00000455186
Q5JR89 [Direct mapping]
Kinesin-like protein KIF2C
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 287 aa
32.4 kDa 		No 0
KIF2C-006
ENSP00000402172
ENST00000423289
H0Y5Z9 [Direct mapping]
Kinesin-like protein KIF2C
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 107 aa
11.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.