Cell atlas - GPR161 - The Human Protein Atlas

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GPR161

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GPR161
Gene description	G protein-coupled receptor 161
Protein class	G-protein coupled receptors Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nucleoli.
RNA cell category	Mixed
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Nucleoli (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA072047
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nucleoli.

Main location

Nucleus (approved)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA072047	CACO-2	Nucleus	Intensity
	HPA072047	HaCaT	Nucleus	Intensity
	HPA072047	HaCaT	Nucleoli	Intensity
	HPA072047	U-2 OS	Nucleus	Intensity

GENE INFORMATION
Gene name	GPR161 (HGNC Symbol)
Synonyms	RE2
Description	G protein-coupled receptor 161 (HGNC Symbol)
Entrez gene summary	Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 [PubMed 18250320]).[supplied by OMIM, Aug 2008]
Chromosome	1
Cytoband	q24.2
Chromosome location (bp)	168079543 - 168137667
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000143147 (version 83.38)
Entrez gene	23432
UniProt	Q8N6U8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N6U8
Antibodypedia	GPR161 antibodies

PROTEIN BROWSER

GPR161-002	GPR161-003	GPR161-004	GPR161-201	GPR161-202	GPR161-203	GPR161-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR161-002 ENSP00000356812 ENST00000367838	Q8N6U8 [Direct mapping] G-protein coupled receptor 161 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007606 [sensory perception of chemical stimulus] GO:0008227 [G-protein coupled amine receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030666 [endocytic vesicle membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0055037 [recycling endosome] GO:0060170 [ciliary membrane] GO:0072372 [primary cilium] GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning] Show all	529 aa 58.6 kDa	No	7
GPR161-003 ENSP00000356809 ENST00000367835	Q8N6U8 [Direct mapping] G-protein coupled receptor 161 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007606 [sensory perception of chemical stimulus] GO:0008227 [G-protein coupled amine receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030666 [endocytic vesicle membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0055037 [recycling endosome] GO:0060170 [ciliary membrane] GO:0072372 [primary cilium] GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning] Show all	529 aa 58.6 kDa	No	7
GPR161-004 ENSP00000356810 ENST00000367836	Q8N6U8 [Direct mapping] G-protein coupled receptor 161 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007606 [sensory perception of chemical stimulus] GO:0008227 [G-protein coupled amine receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030666 [endocytic vesicle membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0055037 [recycling endosome] GO:0060170 [ciliary membrane] GO:0072372 [primary cilium] GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning] Show all	397 aa 43.9 kDa	No	4
GPR161-201 ENSP00000271357 ENST00000271357	A0A0A0MQW8 [Direct mapping] G protein-coupled receptor 161, isoform CRA_b; G-protein-coupled receptor 161 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007606 [sensory perception of chemical stimulus] GO:0008227 [G-protein coupled amine receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0072372 [primary cilium] Show all	546 aa 60.4 kDa	No	7
GPR161-202 ENSP00000441039 ENST00000537209	Q8N6U8 [Direct mapping] G-protein coupled receptor 161 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007606 [sensory perception of chemical stimulus] GO:0008227 [G-protein coupled amine receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030666 [endocytic vesicle membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0055037 [recycling endosome] GO:0060170 [ciliary membrane] GO:0072372 [primary cilium] GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning] Show all	549 aa 60.7 kDa	No	7
GPR161-203 ENSP00000437576 ENST00000539777	Q8N6U8 [Direct mapping] G-protein coupled receptor 161 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007606 [sensory perception of chemical stimulus] GO:0008227 [G-protein coupled amine receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030666 [endocytic vesicle membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0055037 [recycling endosome] GO:0060170 [ciliary membrane] GO:0072372 [primary cilium] GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning] Show all	451 aa 49.7 kDa	No	4
GPR161-204 ENSP00000444348 ENST00000546300	Q8N6U8 [Direct mapping] G-protein coupled receptor 161 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007606 [sensory perception of chemical stimulus] GO:0008227 [G-protein coupled amine receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030666 [endocytic vesicle membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0055037 [recycling endosome] GO:0060170 [ciliary membrane] GO:0072372 [primary cilium] GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning] Show all	415 aa 46 kDa	No	4

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.