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RXRG

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GENERAL INFORMATION

Gene name

 RXRG

Gene description

 Retinoid X receptor, gamma

Protein class

 Cancer-related genes
FDA approved drug targets
Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (SK-MEL-30)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SK-MEL-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 RXRG (HGNC Symbol)

Synonyms

 NR2B3

Description

 Retinoid X receptor, gamma (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 165400917 - 165445355

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143171 (version 83.38)

Entrez gene

 6258

UniProt

 P48443 (UniProt - Evidence at protein level)

neXtProt

 NX_P48443

Antibodypedia

 RXRG antibodies

PROTEIN BROWSER
RXRG-001
RXRG-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RXRG-001
ENSP00000352900
ENST00000359842
P48443 [Direct mapping]
Retinoic acid receptor RXR-gamma
F1D8Q7 [Target identity:100%; Query identity:100%]
Retinoic acid receptor RXR-gamma; Retinoid X nuclear receptor gamma variant 1
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Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004886 [9-cis retinoic acid receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051289 [protein homotetramerization]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]
Show all
 463 aa
50.9 kDa 		No 0
RXRG-201
ENSP00000482458
ENST00000619224
A0A087WZ88 [Direct mapping]
Retinoic acid receptor RXR-gamma
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Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 340 aa
38.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.