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RXRG

GENERAL INFORMATION

Gene name

 RXRG

Gene description

 Retinoid X receptor, gamma

Protein class

 Cancer-related genes
FDA approved drug targets
Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (melanoma, thyroid cancer)
HPA (cell line):Cell line enriched (SK-MEL-30)
HPA (normal tissue):Tissue enhanced (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending retesting.

Reliability score

 Uncertain based on 1 antibody.
CAB002615
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable).
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (melanoma, thyroid cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB002615

GENE INFORMATION

Gene name

 RXRG (HGNC Symbol)

Synonyms

 NR2B3

Description

 Retinoid X receptor, gamma (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 165400917 - 165445355

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143171 (version 83.38)

Entrez gene

 6258

UniProt

 P48443 (UniProt - Evidence at protein level)

neXtProt

 NX_P48443

Antibodypedia

 RXRG antibodies

PROTEIN BROWSER
RXRG-001
RXRG-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RXRG-001
ENSP00000352900
ENST00000359842
P48443 [Direct mapping]
Retinoic acid receptor RXR-gamma
F1D8Q7 [Target identity:100%; Query identity:100%]
Retinoic acid receptor RXR-gamma; Retinoid X nuclear receptor gamma variant 1
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Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004886 [9-cis retinoic acid receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051289 [protein homotetramerization]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]
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 463 aa
50.9 kDa 		No 0
RXRG-201
ENSP00000482458
ENST00000619224
A0A087WZ88 [Direct mapping]
Retinoic acid receptor RXR-gamma
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Predicted intracellular proteins
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
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 340 aa
38.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.