Cell atlas - FCGR2A - The Human Protein Atlas

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FCGR2A

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	FCGR2A
Gene description	Fc fragment of IgG, low affinity IIa, receptor (CD32)
Protein class	CD markers FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (HMC-1, THP-1, HEL, U-937)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, THP-1, HEL, U-937) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	FCGR2A (HGNC Symbol)
Synonyms	CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, IGFR2
Description	Fc fragment of IgG, low affinity IIa, receptor (CD32) (HGNC Symbol)
Entrez gene summary	This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	161505430 - 161524013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143226 (version 83.38)
Entrez gene	2212
UniProt	P12318 (UniProt - Evidence at protein level)
neXtProt	NX_P12318
Antibodypedia	FCGR2A antibodies

PROTEIN BROWSER

FCGR2A-001	FCGR2A-002	FCGR2A-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCGR2A-001 ENSP00000271450 ENST00000271450	P12318 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0019864 [IgG binding] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	317 aa 35 kDa	Yes	1
FCGR2A-002 ENSP00000356949 ENST00000367972	P12318 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0019864 [IgG binding] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	316 aa 34.9 kDa	Yes	1
FCGR2A-017 ENSP00000476411 ENST00000459885	V9GY55 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 9.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.