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FCGR2A

GENERAL INFORMATION

Gene name

 FCGR2A

Gene description

 Fc fragment of IgG, low affinity IIa, receptor (CD32)

Protein class

 CD markers
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix, placenta)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in hematopoietic cells, macrophages and subsets of lymphoid cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA010718 , HPA014730
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FCGR2A (HGNC Symbol)

Synonyms

 CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, IGFR2

Description

 Fc fragment of IgG, low affinity IIa, receptor (CD32) (HGNC Symbol)

Entrez gene summary

 This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 161505430 - 161524013

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143226 (version 83.38)

Entrez gene

 2212

UniProt

 P12318 (UniProt - Evidence at protein level)

neXtProt

 NX_P12318

Antibodypedia

 FCGR2A antibodies

PROTEIN BROWSER
FCGR2A-001
FCGR2A-002
FCGR2A-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FCGR2A-001
ENSP00000271450
ENST00000271450
P12318 [Direct mapping]
Low affinity immunoglobulin gamma Fc region receptor II-a
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0019864 [IgG binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
Show all
 317 aa
35 kDa 		Yes 1
FCGR2A-002
ENSP00000356949
ENST00000367972
P12318 [Direct mapping]
Low affinity immunoglobulin gamma Fc region receptor II-a
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0019864 [IgG binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
Show all
 316 aa
34.9 kDa 		Yes 1
FCGR2A-017
ENSP00000476411
ENST00000459885
V9GY55 [Direct mapping]
Low affinity immunoglobulin gamma Fc region receptor II-a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 86 aa
9.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.