Expression of PRCC in cancer - Summary - The Human Protein Atlas

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PRCC

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRCC
Gene description	Papillary renal cell carcinoma (translocation-associated)
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Cytoplasmic positivity was viewed as off target and disregarded.
Reliability score	Supported based on 3 antibodies. HPA019463 , HPA019481 , CAB017151
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), thyroid cancer (unfavourable), endometrial cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019463	HPA019481	CAB017151

GENE INFORMATION
Gene name	PRCC (HGNC Symbol)
Synonyms	RCCP1
Description	Papillary renal cell carcinoma (translocation-associated) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]
Chromosome	1
Cytoband	q23.1
Chromosome location (bp)	156750610 - 156800817
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143294 (version 83.38)
Entrez gene	5546
UniProt	Q92733 (UniProt - Evidence at protein level)
neXtProt	NX_Q92733
Antibodypedia	PRCC antibodies

PROTEIN BROWSER

PRCC-001	PRCC-004	PRCC-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRCC-001 ENSP00000271526 ENST00000271526	Q92733 [Direct mapping] Proline-rich protein PRCC Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0007093 [mitotic cell cycle checkpoint] GO:0043231 [intracellular membrane-bounded organelle] Show all	491 aa 52.4 kDa	No	0
PRCC-004 ENSP00000403560 ENST00000454659	H0Y679 [Direct mapping] Proline-rich protein PRCC Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		257 aa 28.9 kDa	No	0
PRCC-008 ENSP00000434762 ENST00000526188	H0YE12 [Direct mapping] Proline-rich protein PRCC Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0043231 [intracellular membrane-bounded organelle] Show all	198 aa 22.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.