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RGS16

GENERAL INFORMATION

Gene name

 RGS16

Gene description

 Regulator of G-protein signaling 16

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Daudi, SCLC-21H, U-266/70, U-698)
HPA (normal tissue):Tissue enriched (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA053250 , HPA055824
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA053250
HPA055824

GENE INFORMATION

Gene name

 RGS16 (HGNC Symbol)

Synonyms

 A28-RGS14, RGS-r

Description

 Regulator of G-protein signaling 16 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q25.3

Chromosome location (bp)

 182598623 - 182604408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143333 (version 83.38)

Entrez gene

 6004

UniProt

 O15492 (UniProt - Evidence at protein level)

neXtProt

 NX_O15492

Antibodypedia

 RGS16 antibodies

PROTEIN BROWSER
RGS16-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RGS16-001
ENSP00000356529
ENST00000367558
O15492 [Direct mapping]
Regulator of G-protein signaling 16
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Predicted intracellular proteins
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GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007601 [visual perception]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0045121 [membrane raft]
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 202 aa
22.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.