Expression of TUFT1 in cancer - Summary - The Human Protein Atlas

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TUFT1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TUFT1
Gene description	Tuftelin 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA028112 , HPA054301
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028112	HPA054301

GENE INFORMATION
Gene name	TUFT1
Synonyms
Description	Tuftelin 1 (HGNC Symbol)
Entrez gene summary	Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	151540305 - 151583583
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143367 (version 83.38)
Entrez gene	7286
UniProt	Q9NNX1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NNX1
Antibodypedia	TUFT1 antibodies

PROTEIN BROWSER

TUFT1-006	TUFT1-008	TUFT1-010	TUFT1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TUFT1-006 ENSP00000357842 ENST00000368849	Q9NNX1 [Direct mapping] Tuftelin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030282 [bone mineralization] GO:0030345 [structural constituent of tooth enamel] GO:0042476 [odontogenesis] Show all	390 aa 44.3 kDa	No	0
TUFT1-008 ENSP00000357841 ENST00000368848	Q9NNX1 [Direct mapping] Tuftelin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030282 [bone mineralization] GO:0030345 [structural constituent of tooth enamel] GO:0042476 [odontogenesis] Show all	365 aa 41.5 kDa	No	0
TUFT1-010 ENSP00000376476 ENST00000392712	A6PVU8 [Direct mapping] Tuftelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		335 aa 38 kDa	No	0
TUFT1-201 ENSP00000343781 ENST00000353024	Q6UWW7 [Direct mapping] TUFT1; Tuftelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		199 aa 22.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.