Expression of ANP32E in cancer - Summary - The Human Protein Atlas

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ANP32E

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANP32E
Gene description	Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Supported based on 3 antibodies. HPA063133 , HPA067561 , CAB021114
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA063133	HPA067561	CAB021114

GENE INFORMATION
Gene name	ANP32E (HGNC Symbol)
Synonyms	LANP-L, LANPL, MGC5350
Description	Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q21.2
Chromosome location (bp)	150218417 - 150236156
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143401 (version 83.38)
Entrez gene	81611
UniProt	Q9BTT0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BTT0
Antibodypedia	ANP32E antibodies

PROTEIN BROWSER

ANP32E-001	ANP32E-002	ANP32E-003	ANP32E-004	ANP32E-005	ANP32E-006	ANP32E-007	ANP32E-008	ANP32E-009	ANP32E-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANP32E-001 ENSP00000463154 ENST00000583931	Q9BTT0 [Direct mapping] Acidic leucine-rich nuclear phosphoprotein 32 family member E Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000812 [Swr1 complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0019212 [phosphatase inhibitor activity] GO:0042393 [histone binding] GO:0043086 [negative regulation of catalytic activity] GO:0043486 [histone exchange] Show all	268 aa 30.7 kDa	No	0
ANP32E-002 ENSP00000481415 ENST00000616917	Q9BTT0 [Direct mapping] Acidic leucine-rich nuclear phosphoprotein 32 family member E Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000812 [Swr1 complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0019212 [phosphatase inhibitor activity] GO:0042393 [histone binding] GO:0043486 [histone exchange] Show all	220 aa 25.1 kDa	No	0
ANP32E-003 ENSP00000358111 ENST00000369115	Q5TB25 [Direct mapping] Acidic (Leucine-rich) nuclear phosphoprotein 32 family, member E; Acidic leucine-rich nuclear phosphoprotein 32 family member E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 15.9 kDa	No	0
ANP32E-004 ENSP00000358110 ENST00000369114	Q5TB19 [Direct mapping] Acidic (Leucine-rich) nuclear phosphoprotein 32 family, member E; Acidic leucine-rich nuclear phosphoprotein 32 family member E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	149 aa 16.9 kDa	No	0
ANP32E-005 ENSP00000393718 ENST00000436748	Q9BTT0 [Direct mapping] Acidic leucine-rich nuclear phosphoprotein 32 family member E Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000812 [Swr1 complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0019212 [phosphatase inhibitor activity] GO:0042393 [histone binding] GO:0043486 [histone exchange] Show all	227 aa 26.3 kDa	No	0
ANP32E-006 ENSP00000435215 ENST00000533654	E9PLC4 [Direct mapping] Acidic leucine-rich nuclear phosphoprotein 32 family member E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	165 aa 19.6 kDa	No	0
ANP32E-007 ENSP00000432684 ENST00000532744	E9PPH5 [Direct mapping] Acidic leucine-rich nuclear phosphoprotein 32 family member E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	114 aa 13.1 kDa	No	0
ANP32E-008 ENSP00000436529 ENST00000534220	E9PI45 [Direct mapping] Acidic leucine-rich nuclear phosphoprotein 32 family member E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		105 aa 12.2 kDa	No	0
ANP32E-009 ENSP00000431434 ENST00000534437	H0YCE2 [Direct mapping] Acidic leucine-rich nuclear phosphoprotein 32 family member E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		100 aa 11.8 kDa	No	0
ANP32E-201 ENSP00000487027 ENST00000629042	Q5TB25 [Direct mapping] Acidic (Leucine-rich) nuclear phosphoprotein 32 family, member E; Acidic leucine-rich nuclear phosphoprotein 32 family member E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 15.9 kDa	No	0

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The Human Protein Atlas

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