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ANXA9

GENERAL INFORMATION

Gene name

 ANXA9

Gene description

 Annexin A9

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (MCF7, T-47d)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA028404 , HPA028698
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028404
HPA028698

GENE INFORMATION

Gene name

 ANXA9 (HGNC Symbol)

Synonyms

 ANX31

Description

 Annexin A9 (HGNC Symbol)

Entrez gene summary

 The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 150982017 - 150995634

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143412 (version 83.38)

Entrez gene

 8416

UniProt

 O76027 (UniProt - Evidence at protein level)

neXtProt

 NX_O76027

Antibodypedia

 ANXA9 antibodies

PROTEIN BROWSER
ANXA9-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANXA9-001
ENSP00000357943
ENST00000368947
O76027 [Direct mapping]
Annexin A9
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001786 [phosphatidylserine binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005829 [cytosol]
GO:0007268 [synaptic transmission]
GO:0009986 [cell surface]
GO:0015464 [acetylcholine receptor activity]
GO:0016337 [single organismal cell-cell adhesion]
GO:0042803 [protein homodimerization activity]
GO:0070062 [extracellular exosome]
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 345 aa
38.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.