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TAF1A

GENERAL INFORMATION

Gene name

 TAF1A

Gene description

 TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA054334
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054334

GENE INFORMATION

Gene name

 TAF1A (HGNC Symbol)

Synonyms

 SL1, TAFI48

Description

 TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]

Chromosome

 1

Cytoband

 q41

Chromosome location (bp)

 222557902 - 222589933

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143498 (version 83.38)

Entrez gene

 9015

UniProt

 Q15573 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15573

Antibodypedia

 TAF1A antibodies

PROTEIN BROWSER
TAF1A-001
TAF1A-002
TAF1A-005
TAF1A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAF1A-001
ENSP00000327072
ENST00000352967
Q15573 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000120 [RNA polymerase I transcription factor complex]
GO:0000183 [chromatin silencing at rDNA]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 450 aa
52.7 kDa 		No 0
TAF1A-002
ENSP00000355856
ENST00000366890
Q15573 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000120 [RNA polymerase I transcription factor complex]
GO:0000183 [chromatin silencing at rDNA]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 336 aa
39.6 kDa 		No 0
TAF1A-005
ENSP00000375755
ENST00000391883
Q5JRA7 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000120 [RNA polymerase I transcription factor complex]
GO:0006360 [transcription from RNA polymerase I promoter]
Show all
 286 aa
33.2 kDa 		No 0
TAF1A-201
ENSP00000339976
ENST00000350027
Q15573 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000120 [RNA polymerase I transcription factor complex]
GO:0000183 [chromatin silencing at rDNA]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 450 aa
52.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.