Expression of ATP8B2 in cancer - Summary - The Human Protein Atlas

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ATP8B2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATP8B2
Gene description	ATPase, aminophospholipid transporter, class I, type 8B, member 2
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA046680
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable) and pancreatic cancer (favourable).
Urothelial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046680

GENE INFORMATION
Gene name	ATP8B2 (HGNC Symbol)
Synonyms	ATPID, KIAA1137
Description	ATPase, aminophospholipid transporter, class I, type 8B, member 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	154325553 - 154351307
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143515 (version 83.38)
Entrez gene	57198
UniProt	P98198 (UniProt - Evidence at protein level)
neXtProt	NX_P98198
Antibodypedia	ATP8B2 antibodies

PROTEIN BROWSER

ATP8B2-001	ATP8B2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP8B2-001 ENSP00000357475 ENST00000368489	P98198 [Direct mapping] Phospholipid-transporting ATPase ID Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007030 [Golgi organization] GO:0008152 [metabolic process] GO:0015914 [phospholipid transport] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] Show all	1223 aa 138.7 kDa	No	>9
ATP8B2-003 ENSP00000357472 ENST00000368487	P98198 [Direct mapping] Phospholipid-transporting ATPase ID Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007030 [Golgi organization] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] Show all	387 aa 44.2 kDa	No	4

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.