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ATP8B2

GENERAL INFORMATION

Gene name

 ATP8B2

Gene description

 ATPase, aminophospholipid transporter, class I, type 8B, member 2

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA046680
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ATP8B2 (HGNC Symbol)

Synonyms

 ATPID, KIAA1137

Description

 ATPase, aminophospholipid transporter, class I, type 8B, member 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 154325553 - 154351307

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143515 (version 83.38)

Entrez gene

 57198

UniProt

 P98198 (UniProt - Evidence at protein level)

neXtProt

 NX_P98198

Antibodypedia

 ATP8B2 antibodies

PROTEIN BROWSER
ATP8B2-001
ATP8B2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP8B2-001
ENSP00000357475
ENST00000368489
P98198 [Direct mapping]
Phospholipid-transporting ATPase ID
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0007030 [Golgi organization]
GO:0008152 [metabolic process]
GO:0015914 [phospholipid transport]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0045332 [phospholipid translocation]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
Show all
 1223 aa
138.7 kDa 		No >9
ATP8B2-003
ENSP00000357472
ENST00000368487
P98198 [Direct mapping]
Phospholipid-transporting ATPase ID
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0007030 [Golgi organization]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0045332 [phospholipid translocation]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
Show all
 387 aa
44.2 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.