Expression of CRNN in cancer - Summary - The Human Protein Atlas

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CRNN

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CRNN
Gene description	Cornulin
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (cervical cancer, head and neck cancer, stomach cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly specific cytoplasmic expression in squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA024343 , CAB026182
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (cervical cancer, head and neck cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024343	CAB026182

GENE INFORMATION
Gene name	CRNN (HGNC Symbol)
Synonyms	C1orf10, SEP53
Description	Cornulin (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ""fused gene"" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	152409243 - 152414263
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143536 (version 83.38)
Entrez gene	49860
UniProt	Q9UBG3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBG3
Antibodypedia	CRNN antibodies

PROTEIN BROWSER

CRNN-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRNN-001 ENSP00000271835 ENST00000271835	Q9UBG3 [Direct mapping] Cornulin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0009408 [response to heat] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0070062 [extracellular exosome] Show all	495 aa 53.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.