Expression of ADAM15 in cancer - Summary - The Human Protein Atlas

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ADAM15

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAM15
Gene description	ADAM metallopeptidase domain 15
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA011633
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), glioma (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Glioma p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011633

GENE INFORMATION
Gene name	ADAM15 (HGNC Symbol)
Synonyms	MDC15
Description	ADAM metallopeptidase domain 15 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	155050566 - 155062775
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143537 (version 83.38)
Entrez gene	8751
UniProt	Q13444 (UniProt - Evidence at protein level)
neXtProt	NX_Q13444
Antibodypedia	ADAM15 antibodies

PROTEIN BROWSER

ADAM15-001	ADAM15-002	ADAM15-019	ADAM15-020	ADAM15-023	ADAM15-024	ADAM15-025	ADAM15-026	ADAM15-027	ADAM15-037

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM15-001 ENSP00000271836 ENST00000271836	Q13444 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 15 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001669 [acrosomal vesicle] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030308 [negative regulation of cell growth] GO:0030336 [negative regulation of cell migration] GO:0030574 [collagen catabolic process] GO:0042995 [cell projection] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:1900121 [negative regulation of receptor binding] Show all	814 aa 87.7 kDa	Yes	1
ADAM15-002 ENSP00000357398 ENST00000368413	Q13444 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 15 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001669 [acrosomal vesicle] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030308 [negative regulation of cell growth] GO:0030336 [negative regulation of cell migration] GO:0030574 [collagen catabolic process] GO:0042995 [cell projection] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:1900121 [negative regulation of receptor binding] Show all	520 aa 55.4 kDa	Yes	1
ADAM15-019 ENSP00000349436 ENST00000356955	Q13444 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 15 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001669 [acrosomal vesicle] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0008584 [male gonad development] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030308 [negative regulation of cell growth] GO:0030336 [negative regulation of cell migration] GO:0030574 [collagen catabolic process] GO:0042246 [tissue regeneration] GO:0042995 [cell projection] GO:0045087 [innate immune response] GO:0060317 [cardiac epithelial to mesenchymal transition] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:1900121 [negative regulation of receptor binding] Show all	863 aa 93 kDa	Yes	1
ADAM15-020 ENSP00000403843 ENST00000449910	Q13444 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 15 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001669 [acrosomal vesicle] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030308 [negative regulation of cell growth] GO:0030336 [negative regulation of cell migration] GO:0030574 [collagen catabolic process] GO:0042995 [cell projection] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:1900121 [negative regulation of receptor binding] Show all	862 aa 92.8 kDa	Yes	1
ADAM15-023 ENSP00000352226 ENST00000359280	Q13444 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 15 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001669 [acrosomal vesicle] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030308 [negative regulation of cell growth] GO:0030336 [negative regulation of cell migration] GO:0030574 [collagen catabolic process] GO:0042995 [cell projection] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:1900121 [negative regulation of receptor binding] Show all	838 aa 90.3 kDa	Yes	1
ADAM15-024 ENSP00000353892 ENST00000360674	Q13444 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 15 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001669 [acrosomal vesicle] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030308 [negative regulation of cell growth] GO:0030336 [negative regulation of cell migration] GO:0030574 [collagen catabolic process] GO:0042995 [cell projection] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:1900121 [negative regulation of receptor binding] Show all	772 aa 83.7 kDa	Yes	1
ADAM15-025 ENSP00000357397 ENST00000368412	Q13444 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 15 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001669 [acrosomal vesicle] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030308 [negative regulation of cell growth] GO:0030336 [negative regulation of cell migration] GO:0030574 [collagen catabolic process] GO:0042995 [cell projection] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:1900121 [negative regulation of receptor binding] Show all	796 aa 86.3 kDa	Yes	1
ADAM15-026 ENSP00000432927 ENST00000531455	Q13444 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 15 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001669 [acrosomal vesicle] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030308 [negative regulation of cell growth] GO:0030336 [negative regulation of cell migration] GO:0030574 [collagen catabolic process] GO:0042995 [cell projection] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:1900121 [negative regulation of receptor binding] Show all	824 aa 88.7 kDa	Yes	1
ADAM15-027 ENSP00000476000 ENST00000447332	Q13444 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 15 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001669 [acrosomal vesicle] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030308 [negative regulation of cell growth] GO:0030336 [negative regulation of cell migration] GO:0030574 [collagen catabolic process] GO:0042995 [cell projection] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:1900121 [negative regulation of receptor binding] Show all	633 aa 68.3 kDa	Yes	0
ADAM15-037 ENSP00000348227 ENST00000355956	Q13444 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 15 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001669 [acrosomal vesicle] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030308 [negative regulation of cell growth] GO:0030336 [negative regulation of cell migration] GO:0030574 [collagen catabolic process] GO:0042995 [cell projection] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:1900121 [negative regulation of receptor binding] Show all	839 aa 90.4 kDa	Yes	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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