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Gene name

Class

Subclass

Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Antibodies

Column

 
 
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ADAM15
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADAM15

Gene description

ADAM metallopeptidase domain 15

Protein class

Enzymes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
HPA011633
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), glioma (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Glioma p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA011633

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed weak to moderate cytoplasmic positivity. Skin and cervical tumors were generally negative.

GENE INFORMATION

Gene name

ADAM15 (HGNC Symbol)

Synonyms

MDC15

Description

ADAM metallopeptidase domain 15 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

155050566 - 155062775

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143537 (version 83.38)

Entrez gene

8751

UniProt

Q13444 (UniProt - Evidence at protein level)

neXtProt

NX_Q13444

Antibodypedia

ADAM15 antibodies

PROTEIN BROWSER

ADAM15-001
ADAM15-002
ADAM15-019
ADAM15-020
ADAM15-023
ADAM15-024
ADAM15-025
ADAM15-026
ADAM15-027
ADAM15-037

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM15-001
ENSP00000271836
ENST00000271836
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
814 aa
87.7 kDa
Yes 1
ADAM15-002
ENSP00000357398
ENST00000368413
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
520 aa
55.4 kDa
Yes 1
ADAM15-019
ENSP00000349436
ENST00000356955
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0008584 [male gonad development]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042246 [tissue regeneration]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
863 aa
93 kDa
Yes 1
ADAM15-020
ENSP00000403843
ENST00000449910
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
862 aa
92.8 kDa
Yes 1
ADAM15-023
ENSP00000352226
ENST00000359280
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
838 aa
90.3 kDa
Yes 1
ADAM15-024
ENSP00000353892
ENST00000360674
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
772 aa
83.7 kDa
Yes 1
ADAM15-025
ENSP00000357397
ENST00000368412
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
796 aa
86.3 kDa
Yes 1
ADAM15-026
ENSP00000432927
ENST00000531455
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
824 aa
88.7 kDa
Yes 1
ADAM15-027
ENSP00000476000
ENST00000447332
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
633 aa
68.3 kDa
Yes 0
ADAM15-037
ENSP00000348227
ENST00000355956
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
839 aa
90.4 kDa
Yes 1

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The Human Protein Atlas project is funded
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