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ADAM15

GENERAL INFORMATION

Gene name

 ADAM15

Gene description

 ADAM metallopeptidase domain 15

Protein class

 Enzymes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA011633
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ADAM15 (HGNC Symbol)

Synonyms

 MDC15

Description

 ADAM metallopeptidase domain 15 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 155050566 - 155062775

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143537 (version 83.38)

Entrez gene

 8751

UniProt

 Q13444 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13444

Antibodypedia

 ADAM15 antibodies

PROTEIN BROWSER
ADAM15-001
ADAM15-002
ADAM15-019
ADAM15-020
ADAM15-023
ADAM15-024
ADAM15-025
ADAM15-026
ADAM15-027
ADAM15-037

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAM15-001
ENSP00000271836
ENST00000271836
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
 814 aa
87.7 kDa 		Yes 1
ADAM15-002
ENSP00000357398
ENST00000368413
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
 520 aa
55.4 kDa 		Yes 1
ADAM15-019
ENSP00000349436
ENST00000356955
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0008584 [male gonad development]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042246 [tissue regeneration]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
 863 aa
93 kDa 		Yes 1
ADAM15-020
ENSP00000403843
ENST00000449910
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
 862 aa
92.8 kDa 		Yes 1
ADAM15-023
ENSP00000352226
ENST00000359280
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
 838 aa
90.3 kDa 		Yes 1
ADAM15-024
ENSP00000353892
ENST00000360674
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
 772 aa
83.7 kDa 		Yes 1
ADAM15-025
ENSP00000357397
ENST00000368412
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
 796 aa
86.3 kDa 		Yes 1
ADAM15-026
ENSP00000432927
ENST00000531455
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
 824 aa
88.7 kDa 		Yes 1
ADAM15-027
ENSP00000476000
ENST00000447332
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
 633 aa
68.3 kDa 		Yes 0
ADAM15-037
ENSP00000348227
ENST00000355956
Q13444 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 15
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001669 [acrosomal vesicle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
GO:1900121 [negative regulation of receptor binding]
Show all
 839 aa
90.4 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.