Expression of KCNN3 in cancer - Summary - The Human Protein Atlas

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KCNN3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KCNN3
Gene description	Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
Protein class	Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (Daudi, HMC-1, Karpas-707, U-266/70)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA017990
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017990

GENE INFORMATION
Gene name	KCNN3 (HGNC Symbol)
Synonyms	hSK3, KCa2.3, SKCA3
Description	Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 (HGNC Symbol)
Entrez gene summary	Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	154697455 - 154870280
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143603 (version 83.38)
Entrez gene	3782
UniProt	Q9UGI6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UGI6
Antibodypedia	KCNN3 antibodies

PROTEIN BROWSER

KCNN3-001	KCNN3-002	KCNN3-003	KCNN3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNN3-001 ENSP00000271915 ENST00000271915	A0A0A0MQW9 [Direct mapping] Small conductance calcium-activated potassium channel protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0071805 [potassium ion transmembrane transport] Show all	731 aa 81.4 kDa	No	7
KCNN3-002 ENSP00000354764 ENST00000361147	Q9UGI6 [Direct mapping] Small conductance calcium-activated potassium channel protein 3 Show all	Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0071805 [potassium ion transmembrane transport] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	426 aa 48.1 kDa	No	5
KCNN3-003 ENSP00000351295 ENST00000358505	Q9UGI6 [Direct mapping] Small conductance calcium-activated potassium channel protein 3 Show all	Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0071805 [potassium ion transmembrane transport] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	418 aa 47.1 kDa	No	4
KCNN3-201 ENSP00000481848 ENST00000618040	A0A087WYJ0 [Direct mapping] Small conductance calcium-activated potassium channel protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0071805 [potassium ion transmembrane transport] Show all	746 aa 82.8 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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