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ILF2

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GENERAL INFORMATION

Gene name

 ILF2

Gene description

 Interleukin enhancer binding factor 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated)

Additional location

 In addition localized to the Nucleoli (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by custom assay

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA007484
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ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli.

Main location

 Nucleus (validated)

Additional location

 Nucleoli (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA007484 A-431 Nucleoplasm Intensity
HPA007484 U-2 OS Nucleus Intensity Intensity
Nucleoli
HPA007484 U-251 MG Nucleoplasm Intensity

CUSTOM DATA

 

 

 
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Thumbnail

Antibody

Cell line

Assay

Description
HPA007484 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. ILF2 is mostly expressed at the G1/S checkpoint, during S and/or G2, and during Mitosis.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to custom assay

GENE INFORMATION

Gene name

 ILF2 (HGNC Symbol)

Synonyms

 NF45

Description

 Interleukin enhancer binding factor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153661788 - 153671048

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143621 (version 83.38)

Entrez gene

 3608

UniProt

 Q12905 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12905

Antibodypedia

 ILF2 antibodies

PROTEIN BROWSER
ILF2-001
ILF2-002
ILF2-003
ILF2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ILF2-001
ENSP00000355011
ENST00000361891
Q12905 [Direct mapping]
Interleukin enhancer-binding factor 2
F4ZW62 [Target identity:100%; Query identity:100%]
NF45
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006955 [immune response]
GO:0016020 [membrane]
GO:0016740 [transferase activity]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 390 aa
43.1 kDa 		No 0
ILF2-002
ENSP00000357670
ENST00000368681
A0A0A0MRL0 [Direct mapping]
Interleukin enhancer-binding factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005524 [ATP binding]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
Show all
 150 aa
16.4 kDa 		No 0
ILF2-003
ENSP00000357673
ENST00000368684
X6R6Z1 [Direct mapping]
Interleukin enhancer-binding factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005524 [ATP binding]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
Show all
 115 aa
12.4 kDa 		No 0
ILF2-201
ENSP00000482909
ENST00000615950
B4DY09 [Direct mapping]
Interleukin enhancer-binding factor 2; cDNA FLJ51660, highly similar to Interleukin enhancer-binding factor 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005524 [ATP binding]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
Show all
 352 aa
38.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.