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ILF2

GENERAL INFORMATION

Gene name

 ILF2

Gene description

 Interleukin enhancer binding factor 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA007484
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007484

GENE INFORMATION

Gene name

 ILF2 (HGNC Symbol)

Synonyms

 NF45

Description

 Interleukin enhancer binding factor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153661788 - 153671048

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143621 (version 83.38)

Entrez gene

 3608

UniProt

 Q12905 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12905

Antibodypedia

 ILF2 antibodies

PROTEIN BROWSER
ILF2-001
ILF2-002
ILF2-003
ILF2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ILF2-001
ENSP00000355011
ENST00000361891
Q12905 [Direct mapping]
Interleukin enhancer-binding factor 2
F4ZW62 [Target identity:100%; Query identity:100%]
NF45
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006955 [immune response]
GO:0016020 [membrane]
GO:0016740 [transferase activity]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
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 390 aa
43.1 kDa 		No 0
ILF2-002
ENSP00000357670
ENST00000368681
A0A0A0MRL0 [Direct mapping]
Interleukin enhancer-binding factor 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0005524 [ATP binding]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
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 150 aa
16.4 kDa 		No 0
ILF2-003
ENSP00000357673
ENST00000368684
X6R6Z1 [Direct mapping]
Interleukin enhancer-binding factor 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0005524 [ATP binding]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
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 115 aa
12.4 kDa 		No 0
ILF2-201
ENSP00000482909
ENST00000615950
B4DY09 [Direct mapping]
Interleukin enhancer-binding factor 2; cDNA FLJ51660, highly similar to Interleukin enhancer-binding factor 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0005524 [ATP binding]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
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 352 aa
38.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.