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RIT1

GENERAL INFORMATION

Gene name

 RIT1

Gene description

 Ras-like without CAAX 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA053249
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA053249

GENE INFORMATION

Gene name

 RIT1 (HGNC Symbol)

Synonyms

 MGC125864, MGC125865, RIBB, RIT, ROC1

Description

 Ras-like without CAAX 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 155897808 - 155911404

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143622 (version 83.38)

Entrez gene

 6016

UniProt

 Q92963 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92963

Antibodypedia

 RIT1 antibodies

PROTEIN BROWSER
RIT1-001
RIT1-002
RIT1-005
RIT1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RIT1-001
ENSP00000357306
ENST00000368323
Q92963 [Direct mapping]
GTP-binding protein Rit1
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
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 219 aa
25.1 kDa 		No 0
RIT1-002
ENSP00000357305
ENST00000368322
Q92963 [Direct mapping]
GTP-binding protein Rit1
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
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 236 aa
27.1 kDa 		No 0
RIT1-005
ENSP00000441950
ENST00000539040
Q92963 [Direct mapping]
GTP-binding protein Rit1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
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 183 aa
21.6 kDa 		No 0
RIT1-006
ENSP00000476612
ENST00000609492
V9GYC3 [Direct mapping]
GTP-binding protein Rit1
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 151 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.