Cell atlas - FLG - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

FLG

premium

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	FLG
Gene description	Filaggrin
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (HaCaT, LHCN-M2)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA027505 , HPA030188
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, LHCN-M2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA027505	HaCaT	Vesicles
	HPA030188	HaCaT	Vesicles

GENE INFORMATION
Gene name	FLG
Synonyms
Description	Filaggrin (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	152302175 - 152325203
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143631 (version 83.38)
Entrez gene	2312
UniProt	P20930 (UniProt - Evidence at protein level)
neXtProt	NX_P20930
Antibodypedia	FLG antibodies

PROTEIN BROWSER

FLG-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FLG-001 ENSP00000357789 ENST00000368799	P20930 [Direct mapping] Filaggrin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005882 [intermediate filament] GO:0007275 [multicellular organismal development] GO:0030216 [keratinocyte differentiation] GO:0036457 [keratohyalin granule] GO:0061436 [establishment of skin barrier] Show all	4061 aa 435.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.