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FLG

GENERAL INFORMATION

Gene name

 FLG

Gene description

 Filaggrin

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Cell line enhanced (HaCaT, LHCN-M2)
HPA (normal tissue):Tissue enriched (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Highly selective cytoplasmic expression in superficial layers in squamous epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA030188 , HPA030189 , CAB002210
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA030188
HPA030189
CAB002210

GENE INFORMATION

Gene name

 FLG

Synonyms

Description

 Filaggrin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 152302175 - 152325203

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143631 (version 83.38)

Entrez gene

 2312

UniProt

 P20930 (UniProt - Evidence at protein level)

neXtProt

 NX_P20930

Antibodypedia

 FLG antibodies

PROTEIN BROWSER
FLG-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FLG-001
ENSP00000357789
ENST00000368799
P20930 [Direct mapping]
Filaggrin
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005882 [intermediate filament]
GO:0007275 [multicellular organismal development]
GO:0030216 [keratinocyte differentiation]
GO:0036457 [keratohyalin granule]
GO:0061436 [establishment of skin barrier]
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 4061 aa
435.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.