Expression of CEP170 in cancer - Summary - The Human Protein Atlas

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CEP170

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CEP170
Gene description	Centrosomal protein 170kDa
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA042151 , HPA045787
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042151	HPA045787

GENE INFORMATION
Gene name	CEP170 (HGNC Symbol)
Synonyms	FAM68A, KAB, KIAA0470
Description	Centrosomal protein 170kDa (HGNC Symbol)
Entrez gene summary	The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q43
Chromosome location (bp)	243124428 - 243255348
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143702 (version 83.38)
Entrez gene	9859
UniProt	Q5SW79 (UniProt - Evidence at protein level)
neXtProt	NX_Q5SW79
Antibodypedia	CEP170 antibodies

PROTEIN BROWSER

CEP170-001	CEP170-002	CEP170-003	CEP170-004	CEP170-006	CEP170-007	CEP170-009	CEP170-010	CEP170-018	CEP170-019	CEP170-020	CEP170-025	CEP170-026

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEP170-001 ENSP00000355502 ENST00000366544	Q5SW79 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0031965 [nuclear membrane] Show all	1486 aa 164.5 kDa	No	0
CEP170-002 ENSP00000355501 ENST00000366543	Q5SW79 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0031965 [nuclear membrane] Show all	1460 aa 161.4 kDa	No	0
CEP170-003 ENSP00000355500 ENST00000366542	Q5SW79 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0031965 [nuclear membrane] Show all	1584 aa 175.3 kDa	No	0
CEP170-004 ENSP00000338161 ENST00000336415	H0Y2V6 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1558 aa 172 kDa	No	0
CEP170-006 ENSP00000430142 ENST00000490813	E7EWM2 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	293 aa 32.7 kDa	No	0
CEP170-007 ENSP00000427842 ENST00000481987	E7EMW0 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	320 aa 35.5 kDa	No	0
CEP170-009 ENSP00000427843 ENST00000464936	E5RG47 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	175 aa 19.9 kDa	No	0
CEP170-010 ENSP00000430112 ENST00000492145	E5RGW7 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.5 kDa	No	0
CEP170-018 ENSP00000428400 ENST00000522995	E5RIH6 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	88 aa 10.1 kDa	No	0
CEP170-019 ENSP00000427944 ENST00000522191	E5RFU8 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	133 aa 15.2 kDa	No	0
CEP170-020 ENSP00000428183 ENST00000523424	E5RJT5 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	111 aa 12.7 kDa	No	0
CEP170-025 ENSP00000428996 ENST00000522895	H0YB92 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	173 aa 19.8 kDa	No	1
CEP170-026 ENSP00000394002 ENST00000413359	H0Y4T4 [Direct mapping] Centrosomal protein of 170 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	263 aa 29.1 kDa	No	0

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