Expression of ACP1 in cancer - Summary - The Human Protein Atlas

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ACP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACP1
Gene description	Acid phosphatase 1, soluble
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA016754
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and melanoma (unfavourable).
Liver cancer p<0.001 Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016754

GENE INFORMATION
Gene name	ACP1 (HGNC Symbol)
Synonyms	HAAP, LMW-PTP
Description	Acid phosphatase 1, soluble (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]
Chromosome	2
Cytoband	p25.3
Chromosome location (bp)	264140 - 278283
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143727 (version 83.38)
Entrez gene	52
UniProt	P24666 (UniProt - Evidence at protein level)
neXtProt	NX_P24666
Antibodypedia	ACP1 antibodies

PROTEIN BROWSER

ACP1-001	ACP1-002	ACP1-004	ACP1-005	ACP1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACP1-001 ENSP00000272065 ENST00000272065	P24666 [Direct mapping] Low molecular weight phosphotyrosine protein phosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0004726 [non-membrane spanning protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0009898 [cytoplasmic side of plasma membrane] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0070062 [extracellular exosome] Show all	158 aa 18 kDa	No	0
ACP1-002 ENSP00000272067 ENST00000272067	P24666 [Direct mapping] Low molecular weight phosphotyrosine protein phosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0004726 [non-membrane spanning protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0009898 [cytoplasmic side of plasma membrane] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0070062 [extracellular exosome] Show all	158 aa 18 kDa	No	0
ACP1-004 ENSP00000385404 ENST00000407983	P24666 [Direct mapping] Low molecular weight phosphotyrosine protein phosphatase Show all	Enzymes ENZYME proteins Hydrolases Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0004726 [non-membrane spanning protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0009898 [cytoplasmic side of plasma membrane] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0070062 [extracellular exosome] Show all	112 aa 12.2 kDa	No	0
ACP1-005 ENSP00000408596 ENST00000439645	D3YTI2 [Direct mapping] Low molecular weight phosphotyrosine protein phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	85 aa 9.5 kDa	No	0
ACP1-006 ENSP00000384307 ENST00000405233	F2Z2Q9 [Direct mapping] Low molecular weight phosphotyrosine protein phosphatase Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	70 aa 7.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.