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A few colorectal, endometrial, testicular, pancreatic, ovarian cancers and gliomas showed moderate to strong cytoplasmic positivity. Other cancer tissues were negative.
Rare cases if carcinoid and endometrial cancer showed strong cytoplasmic immunoreactivity. A few cases of colorectal and ovarian cancers together with a rare case each of glioma and melanoma displayed weak to moderate staining. Remaining cancer tissues were negative.
Cancer tissues displayed weak to moderate cytoplasmic and membranous staining, with a few cases of moderate positivity. Malignant lymphomas and colorectal cancers showed moderate to strong cytoplasmic immunoreactivity.
GENE INFORMATION
Gene name
LEFTY2 (HGNC Symbol)
Synonyms
EBAF, LEFTA, LEFTYA, TGFB4
Description
Left-right determination factor 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010]